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Table 6 Odds ratios (ORs) and corresponding 95% confidence intervals (CI) for the associations between body size at age 18 years and tumor characteristics of breast cancer (case-only analysis)

From: Body size in early life and risk of breast cancer

 

KARMA

LIBRO1

Combined

 

Number

Multivariable OR (95% CI)a

Number

Multivariable OR (95% CI)a

Number

Multivariable OR (95% CI)b

ER status

 

ER-negative

ER-positive

 

ER-negative

ER-positive

 

ER-negative

ER-positive

 

Body size, age 18

         

 Small

58

463

1.00 (Reference)

164

994

1.00 (Reference)

222

1457

1.00 (Reference)

 Medium

142

927

0.85 (0.59–1.24)

311

1733

0.91 (0.74–1.12)

453

2660

0.90 (0.76–1.08)

 Large

11

119

1.05 (0.50–2.19)

37

222

1.00 (0.68–1.47)

48

341

1.01 (0.72–1.43)

  P trend

  

0.880

  

0.783

  

0.791

Tumor size

 

T0–T1

T2–T4

 

T0–T1

T2–T4

 

T0–T1

T2–T4

 

Body size, age 18

         

 Small

368

190

1.00 (Reference)

739

329

1.00 (Reference)

1107

519

1.00 (Reference)

 Medium

867

321

0.75 (0.58–0.96)

1365

587

0.97 (0.82–1.14)

2232

908

0.90 (0.78–1.03)

 Large

99

38

0.54 (0.32–0.92)

174

72

0.87 (0.64–1.18)

273

110

0.77 (0.59–1.00)

  P trend

  

0.008

  

0.379

  

0.030

Lymph node involvement

 

No

Yes

 

No

Yes

 

No

Yes

 

Body size, age 18

         

 Small

447

108

1.00 (Reference)

955

107

1.00 (Reference)

1402

215

1.00 (Reference)

 Medium

980

196

0.83 (0.62–1.12)

1700

239

1.28 (1.00–1.63)

1219

435

1.10 (0.91–1.33)

 Large

108

29

1.21 (0.70–2.07)

213

32

1.30 (0.85–1.99)

321

61

1.26 (0.91–1.76)

  P trend

  

0.812

  

0.122

  

0.140

  1. Number is the number of cases. ER estrogen receptor, T tumor size
  2. aAdjusted for age, age at menarche, number of children, ever use of hormone replacement therapy and family history of breast cancer
  3. bAdjusted for age, age at menarche, number of children, ever use of hormone replacement therapy, family history of breast cancer and study