| |
KARMA
|
LIBRO1
|
Combined
|
|---|
| |
Number
|
Multivariable OR (95% CI)a
|
Number
|
Multivariable OR (95% CI)a
|
Number
|
Multivariable OR (95% CI)b
|
|---|
|
ER status
|
| |
ER-negative
|
ER-positive
| |
ER-negative
|
ER-positive
| |
ER-negative
|
ER-positive
| |
|
Body size, age 18
| | | | | | | | | |
|
Small
|
58
|
463
|
1.00 (Reference)
|
164
|
994
|
1.00 (Reference)
|
222
|
1457
|
1.00 (Reference)
|
|
Medium
|
142
|
927
|
0.85 (0.59–1.24)
|
311
|
1733
|
0.91 (0.74–1.12)
|
453
|
2660
|
0.90 (0.76–1.08)
|
|
Large
|
11
|
119
|
1.05 (0.50–2.19)
|
37
|
222
|
1.00 (0.68–1.47)
|
48
|
341
|
1.01 (0.72–1.43)
|
|
P
trend
| | |
0.880
| | |
0.783
| | |
0.791
|
|
Tumor size
|
| |
T0–T1
|
T2–T4
| |
T0–T1
|
T2–T4
| |
T0–T1
|
T2–T4
| |
|
Body size, age 18
| | | | | | | | | |
|
Small
|
368
|
190
|
1.00 (Reference)
|
739
|
329
|
1.00 (Reference)
|
1107
|
519
|
1.00 (Reference)
|
|
Medium
|
867
|
321
|
0.75 (0.58–0.96)
|
1365
|
587
|
0.97 (0.82–1.14)
|
2232
|
908
|
0.90 (0.78–1.03)
|
|
Large
|
99
|
38
|
0.54 (0.32–0.92)
|
174
|
72
|
0.87 (0.64–1.18)
|
273
|
110
|
0.77 (0.59–1.00)
|
|
P
trend
| | |
0.008
| | |
0.379
| | |
0.030
|
|
Lymph node involvement
|
| |
No
|
Yes
| |
No
|
Yes
| |
No
|
Yes
| |
|
Body size, age 18
| | | | | | | | | |
|
Small
|
447
|
108
|
1.00 (Reference)
|
955
|
107
|
1.00 (Reference)
|
1402
|
215
|
1.00 (Reference)
|
|
Medium
|
980
|
196
|
0.83 (0.62–1.12)
|
1700
|
239
|
1.28 (1.00–1.63)
|
1219
|
435
|
1.10 (0.91–1.33)
|
|
Large
|
108
|
29
|
1.21 (0.70–2.07)
|
213
|
32
|
1.30 (0.85–1.99)
|
321
|
61
|
1.26 (0.91–1.76)
|
|
P
trend
| | |
0.812
| | |
0.122
| | |
0.140
|
- Number is the number of cases. ER estrogen receptor, T tumor size
-
aAdjusted for age, age at menarche, number of children, ever use of hormone replacement therapy and family history of breast cancer
-
bAdjusted for age, age at menarche, number of children, ever use of hormone replacement therapy, family history of breast cancer and study
