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Table 6 Odds ratios (ORs) and corresponding 95% confidence intervals (CI) for the associations between body size at age 18 years and tumor characteristics of breast cancer (case-only analysis)

From: Body size in early life and risk of breast cancer

  KARMA LIBRO1 Combined
  Number Multivariable OR (95% CI)a Number Multivariable OR (95% CI)a Number Multivariable OR (95% CI)b
ER status
  ER-negative ER-positive   ER-negative ER-positive   ER-negative ER-positive  
Body size, age 18          
 Small 58 463 1.00 (Reference) 164 994 1.00 (Reference) 222 1457 1.00 (Reference)
 Medium 142 927 0.85 (0.59–1.24) 311 1733 0.91 (0.74–1.12) 453 2660 0.90 (0.76–1.08)
 Large 11 119 1.05 (0.50–2.19) 37 222 1.00 (0.68–1.47) 48 341 1.01 (0.72–1.43)
P trend    0.880    0.783    0.791
Tumor size
  T0–T1 T2–T4   T0–T1 T2–T4   T0–T1 T2–T4  
Body size, age 18          
 Small 368 190 1.00 (Reference) 739 329 1.00 (Reference) 1107 519 1.00 (Reference)
 Medium 867 321 0.75 (0.58–0.96) 1365 587 0.97 (0.82–1.14) 2232 908 0.90 (0.78–1.03)
 Large 99 38 0.54 (0.32–0.92) 174 72 0.87 (0.64–1.18) 273 110 0.77 (0.59–1.00)
P trend    0.008    0.379    0.030
Lymph node involvement
  No Yes   No Yes   No Yes  
Body size, age 18          
 Small 447 108 1.00 (Reference) 955 107 1.00 (Reference) 1402 215 1.00 (Reference)
 Medium 980 196 0.83 (0.62–1.12) 1700 239 1.28 (1.00–1.63) 1219 435 1.10 (0.91–1.33)
 Large 108 29 1.21 (0.70–2.07) 213 32 1.30 (0.85–1.99) 321 61 1.26 (0.91–1.76)
P trend    0.812    0.122    0.140
  1. Number is the number of cases. ER estrogen receptor, T tumor size
  2. aAdjusted for age, age at menarche, number of children, ever use of hormone replacement therapy and family history of breast cancer
  3. bAdjusted for age, age at menarche, number of children, ever use of hormone replacement therapy, family history of breast cancer and study