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Table 6 Odds ratios (ORs) and corresponding 95% confidence intervals (CI) for the associations between body size at age 18 years and tumor characteristics of breast cancer (case-only analysis)
| KARMA | LIBRO1 | Combined | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Number | Multivariable OR (95% CI)a | Number | Multivariable OR (95% CI)a | Number | Multivariable OR (95% CI)b | ||||
| ER status | |||||||||
| ER-negative | ER-positive | ER-negative | ER-positive | ER-negative | ER-positive | ||||
| Body size, age 18 | |||||||||
| Small | 58 | 463 | 1.00 (Reference) | 164 | 994 | 1.00 (Reference) | 222 | 1457 | 1.00 (Reference) |
| Medium | 142 | 927 | 0.85 (0.59–1.24) | 311 | 1733 | 0.91 (0.74–1.12) | 453 | 2660 | 0.90 (0.76–1.08) |
| Large | 11 | 119 | 1.05 (0.50–2.19) | 37 | 222 | 1.00 (0.68–1.47) | 48 | 341 | 1.01 (0.72–1.43) |
| P trend | 0.880 | 0.783 | 0.791 | ||||||
| Tumor size | |||||||||
| T0–T1 | T2–T4 | T0–T1 | T2–T4 | T0–T1 | T2–T4 | ||||
| Body size, age 18 | |||||||||
| Small | 368 | 190 | 1.00 (Reference) | 739 | 329 | 1.00 (Reference) | 1107 | 519 | 1.00 (Reference) |
| Medium | 867 | 321 | 0.75 (0.58–0.96) | 1365 | 587 | 0.97 (0.82–1.14) | 2232 | 908 | 0.90 (0.78–1.03) |
| Large | 99 | 38 | 0.54 (0.32–0.92) | 174 | 72 | 0.87 (0.64–1.18) | 273 | 110 | 0.77 (0.59–1.00) |
| P trend | 0.008 | 0.379 | 0.030 | ||||||
| Lymph node involvement | |||||||||
| No | Yes | No | Yes | No | Yes | ||||
| Body size, age 18 | |||||||||
| Small | 447 | 108 | 1.00 (Reference) | 955 | 107 | 1.00 (Reference) | 1402 | 215 | 1.00 (Reference) |
| Medium | 980 | 196 | 0.83 (0.62–1.12) | 1700 | 239 | 1.28 (1.00–1.63) | 1219 | 435 | 1.10 (0.91–1.33) |
| Large | 108 | 29 | 1.21 (0.70–2.07) | 213 | 32 | 1.30 (0.85–1.99) | 321 | 61 | 1.26 (0.91–1.76) |
| P trend | 0.812 | 0.122 | 0.140 | ||||||
