Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 5 Odds ratios (ORs) and corresponding 95% confidence intervals (CI) for the associations between body size at age 7 years and tumor characteristics of breast cancer (case-only analysis)

From: Body size in early life and risk of breast cancer

  KARMA LIBRO1 Combined
  Number Multivariable OR (95% CI)a Number Multivariable OR (95% CI)a Number Multivariable OR (95% CI)b
ER status
  ER-negative ER-positive   ER-negative ER-positive   ER-negative ER-positive  
Body size, age 7          
 Small 107 848 1.00 (Reference) 317 1958 1.00 (Reference) 424 2806 1.00 (Reference)
 Medium 81 514 0.91 (0.63–1.30) 184 966 0.87 (0.71–1.07) 265 1480 0.89 (0.74–1.06)
 Large 20 107 0.56 (0.31–0.99) 43 270 1.02 (0.71–1.46) 63 377 0.88 (0.65–1.19)
P trend    0.062    0.717    0.234
Tumor size
  T0–T1 T2–T4   T0–T1 T2–T4   T0–T1 T2–T4  
Body size, age 7          
 Small 729 325 1.00 (Reference) 1482 656 1.00 (Reference) 2211 981 1.00 (Reference)
 Medium 471 176 0.86 (0.66–1.10) 757 327 0.95 (0.80–1.12) 1228 503 0.92 (0.80–1.05)
 Large 101 37 0.70 (0.43–1.15) 211 100 0.98 (0.75–1.29) 312 137 0.90 (0.71–1.15)
P trend    0.098    0.762    0.255
Lymph node involvement
  No Yes   No Yes   No Yes  
Body size, age 7          
 Small 843 195 1.00 (Reference) 1889 237 1.00 (Reference) 2732 432 1.00 (Reference)
 Medium 542 108 0.93 (0.69–1.25) 943 134 1.14 (0.90–1.44) 1485 242 1.08 (0.90–1.29)
 Large 110 27 1.24 (0.74–2.09) 277 33 0.99 (0.66–1.47) 387 60 1.06 (0.77–1.44)
P trend    0.611    0.769    0.572
  1. Number is the number of cases. ER estrogen receptor, T tumor size
  2. aAdjusted for age, age at menarche, number of children, ever use of hormone replacement therapy and family history of breast cancer
  3. bAdjusted for age, age at menarche, number of children, ever use of hormone replacement therapy, family history of breast cancer and study