Breast Cancer Research

Table 5 Odds ratios (ORs) and corresponding 95% confidence intervals (CI) for the associations between body size at age 7 years and tumor characteristics of breast cancer (case-only analysis)

From: Body size in early life and risk of breast cancer

	KARMA			LIBRO1			Combined
	Number		Multivariable OR (95% CI)^a	Number		Multivariable OR (95% CI)^a	Number		Multivariable OR (95% CI)^b
ER status
	ER-negative	ER-positive		ER-negative	ER-positive		ER-negative	ER-positive
Body size, age 7
Small	107	848	1.00 (Reference)	317	1958	1.00 (Reference)	424	2806	1.00 (Reference)
Medium	81	514	0.91 (0.63–1.30)	184	966	0.87 (0.71–1.07)	265	1480	0.89 (0.74–1.06)
Large	20	107	0.56 (0.31–0.99)	43	270	1.02 (0.71–1.46)	63	377	0.88 (0.65–1.19)
P _trend			0.062			0.717			0.234
Tumor size
	T0–T1	T2–T4		T0–T1	T2–T4		T0–T1	T2–T4
Body size, age 7
Small	729	325	1.00 (Reference)	1482	656	1.00 (Reference)	2211	981	1.00 (Reference)
Medium	471	176	0.86 (0.66–1.10)	757	327	0.95 (0.80–1.12)	1228	503	0.92 (0.80–1.05)
Large	101	37	0.70 (0.43–1.15)	211	100	0.98 (0.75–1.29)	312	137	0.90 (0.71–1.15)
P _trend			0.098			0.762			0.255
Lymph node involvement
	No	Yes		No	Yes		No	Yes
Body size, age 7
Small	843	195	1.00 (Reference)	1889	237	1.00 (Reference)	2732	432	1.00 (Reference)
Medium	542	108	0.93 (0.69–1.25)	943	134	1.14 (0.90–1.44)	1485	242	1.08 (0.90–1.29)
Large	110	27	1.24 (0.74–2.09)	277	33	0.99 (0.66–1.47)	387	60	1.06 (0.77–1.44)
P _trend			0.611			0.769			0.572

Number is the number of cases. ER estrogen receptor, T tumor size
^aAdjusted for age, age at menarche, number of children, ever use of hormone replacement therapy and family history of breast cancer
^bAdjusted for age, age at menarche, number of children, ever use of hormone replacement therapy, family history of breast cancer and study

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ISSN: 1465-542X

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