Table 4 Odds ratios (ORs) and corresponding 95% confidence intervals (CI) for the association between body size change from childhood to adolescence and overall risk of breast cancer
| Â | KARMA | LIBRO1 | Combined | ||||||
|---|---|---|---|---|---|---|---|---|---|
Body size change | n | Age-adjusted OR (95% CI) | Multivariable OR (95% CI)a | n | Age-adjusted OR (95% CI) | Multivariable OR (95% CI)a | n | Age-adjusted OR (95% CI) | Multivariable OR (95% CI)b |
Remained small | 615 | 1.00 (Reference) | 1.00 (Reference) | 1320 | 1.00 (Reference) | 1.00 (Reference) | 1935 | 1.00 (Reference) | 1.00 (Reference) |
Decrease | 181 | 0.92 (0.82–1.05) | 0.89 (0.73–1.07) | 382 | 0.92 (0.81–1.05) | 0.91 (0.79–1.04) | 563 | 0.92 (0.83–1.02) | 0.90 (0.81–1.00) |
Remained medium | 626 | 0.93 (0.82–1.05) | 0.91 (0.80–1.03) | 1067 | 0.73 (0.67–0.80) | 0.73 (0.66–0.80) | 1693 | 0.79 (0.74–0.85) | 0.79 (0.73–0.85) |
Increase | 784 | 1.06 (0.94–1.19) | 1.04 (0.92–1.17) | 1555 | 0.91 (0.83–0.99) | 0.91 (0.84–0.99) | 2339 | 0.95 (0.89–1.02) | 0.95 (0.89–1.02) |
Remained large | 66 | 0.78 (0.59–1.03) | 0.75 (0.56–0.99) | 130 | 0.63 (0.51–0.77) | 0.63 (0.52–0.77) | 196 | 0.67 (0.57–0.79) | 0.67 (0.57–0.79) |