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Table 4 Odds ratios (ORs) and corresponding 95% confidence intervals (CI) for the association between body size change from childhood to adolescence and overall risk of breast cancer

From: Body size in early life and risk of breast cancer

  KARMA LIBRO1 Combined
Body size change n Age-adjusted
OR (95% CI)
Multivariable
OR (95% CI)a
n Age-adjusted
OR (95% CI)
Multivariable
OR (95% CI)a
n Age-adjusted
OR (95% CI)
Multivariable
OR (95% CI)b
Remained small 615 1.00 (Reference) 1.00 (Reference) 1320 1.00 (Reference) 1.00 (Reference) 1935 1.00 (Reference) 1.00 (Reference)
Decrease 181 0.92 (0.82–1.05) 0.89 (0.73–1.07) 382 0.92 (0.81–1.05) 0.91 (0.79–1.04) 563 0.92 (0.83–1.02) 0.90 (0.81–1.00)
Remained medium 626 0.93 (0.82–1.05) 0.91 (0.80–1.03) 1067 0.73 (0.67–0.80) 0.73 (0.66–0.80) 1693 0.79 (0.74–0.85) 0.79 (0.73–0.85)
Increase 784 1.06 (0.94–1.19) 1.04 (0.92–1.17) 1555 0.91 (0.83–0.99) 0.91 (0.84–0.99) 2339 0.95 (0.89–1.02) 0.95 (0.89–1.02)
Remained large 66 0.78 (0.59–1.03) 0.75 (0.56–0.99) 130 0.63 (0.51–0.77) 0.63 (0.52–0.77) 196 0.67 (0.57–0.79) 0.67 (0.57–0.79)
  1. n number of breast cancer cases
  2. aAdjusted for age, age at menarche, family history of breast cancer, number of children and ever use of hormone replacement therapy
  3. bAdjusted for study, age, age at menarche, family history of breast cancer, number of children and ever use of hormone replacement therapy