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Table 3 Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for breast cancer risk associated with body size at age 18 years

From: Body size in early life and risk of breast cancer

  KARMA LIBRO1 Combined
Body size Number Age-adjusted
OR (95% CI)
Multivariable
OR (95% CI)a
Number Age-adjusted
OR (95% CI)
Multivariable
OR (95% CI)a
Number Age-adjusted
OR (95% CI)
Multivariable
OR (95% CI)b
Breast cancer overall
 Small 705 1.00 (Reference) 1.00 (Reference) 1482 1.00 (Reference) 1.00 (Reference) 2187 1.00 (Reference) 1.00 (Reference)
 Medium 1407 0.97 (0.87–1.07) 0.95 (0.86–1.06) 2638 0.85 (0.79–0.91) 0.85 (0.79–0.91) 4045 0.89 (0.84–0.94) 0.88 (0.83–0.94)
 Large 160 0.79 (0.66–0.96) 0.78 (0.64–0.94) 334 0.68 (0.59–0.78) 0.69 (0.60–0.79) 494 0.72 (0.65–0.80) 0.72 (0.64–0.80)
P trend   0.005 0.013   <0.001 <0.001   <0.001 <0.001
Premenopausal breast cancer
 Small 214 1.00 (Reference) 1.00 (Reference) 284 1.00 (Reference) 1.00 (Reference) 498 1.00 (Reference) 1.00 (Reference)
 Medium 466 1.06 (0.87–1.31) 1.03 (0.84–1.28) 545 0.82 (0.70–0.97) 0.80 (0.68–0.94) 1011 0.91 (0.80–1.03) 0.88 (0.78–1.00)
 Large 52 0.70 (0.49–1.00) 0.66 (0.46–0.95) 84 0.66 (0.50–0.86) 0.62 (0.47–0.81) 136 0.67 (0.54–0.83) 0.63 (0.51–0.78)
P trend   0.190 0.043   <0.001 <0.001   <0.001 <0.001
Postmenopausal breast cancer
 Small 491 1.00 (Reference) 1.00 (Reference) 1198 1.00 (Reference) 1.00 (Reference) 1689 1.00 (Reference) 1.00 (Reference)
 Medium 941 0.94 (0.83–1.07) 0.93 (0.82–1.06) 2093 0.83 (0.76–0.91) 0.84 (0.77–0.91) 3034 0.87 (0.81–0.93) 0.87 (0.81–0.93)
 Large 108 0.87 (0.69–1.09) 0.86 (0.68–1.09) 250 0.67 (0.57–0.78) 0.69 (0.59–0.81) 358 0.72 (0.63–0.82) 0.74 (0.64–0.84)
P trend   0.065 0.142   <0.001 <0.001   <0.001 <0.001
  1. Number is the number of breast cancer cases
  2. aAdjusted for age, age at menarche, family history of breast cancer, number of children and ever use of hormone replacement therapy
  3. bAdjusted for study, age, age at menarche, family history of breast cancer, number of children and ever use of hormone replacement therapy