Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for breast cancer risk associated with body size at age 7 years

From: Body size in early life and risk of breast cancer

  KARMA LIBRO1 Combined
Body size Number Age-adjusted
OR (95% CI)
Multivariable
OR (95% CI)a
Number Age-adjusted
OR (95% CI)
Multivariable
OR (95% CI)a
Number Age-adjusted
OR (95% CI)
Multivariable
OR (95% CI)b
Breast cancer overall
 Small 1327 1.00 (Reference) 1.00 (Reference) 2727 1.00 (Reference) 1.00 (Reference) 4054 1.00 (Reference) 1.00 (Reference)
 Medium 773 0.89 (0.80–0.98) 0.88 (0.80–0.98) 1358 0.77 (0.71–0.82) 0.76 (0.71–0.82) 2131 0.81 (0.76–0.86) 0.80 (0.76–0.85)
 Large 172 0.75 (0.63–0.90) 0.73 (0.61–0.87) 374 0.81 (0.72–0.92) 0.80 (0.71–0.91) 546 0.79 (0.72–0.87) 0.78 (0.70–0.86)
P trend   <0.001 <0.001   <0.001 <0.001   <0.001 <0.001
Premenopausal breast cancer
 Small 422 1.00 (Reference) 1.00 (Reference) 534 1.00 (Reference) 1.00 (Reference) 956 1.00 (Reference) 1.00 (Reference)
 Medium 259 0.94 (0.77–1.14) 0.90 (0.74–1.09) 294 0.81 (0.69–0.95) 0.79 (0.67–0.92) 553 0.86 (0.76–0.97) 0.83 (0.73–0.94)
 Large 51 0.63 (0.44–0.90) 0.59 (0.41–0.85) 85 0.86 (0.69–1.11) 0.80 (0.62–1.04) 136 0.77 (0.63–0.95) 0.72 (0.58–0.89)
P trend   0.015 0.004   0.039 0.020   0.003 <0.001
Postmenopausal breast cancer
 Small 905 1.00 (Reference) 1.00 (Reference) 2193 1.00 (Reference) 1.00 (Reference) 3098 1.00 (Reference) 1.00 (Reference)
 Medium 514 0.89 (0.79–1.01) 0.89 (0.78–1.00) 1064 0.76 (0.70–0.83) 0.76 (0.70–0.83) 1578 0.80 (0.75–0.86) 0.80 (0.75–0.86)
 Large 121 0.80 (0.65–0.99) 0.79 (0.64–0.98) 289 0.80 (0.69–0.92) 0.80 (0.70–0.93) 410 0.80 (0.71–0.90) 0.80 (0.71–0.90)
P trend   0.018 0.014   <0.001 <0.001   <0.001 <0.001
  1. Number is the number of breast cancer cases
  2. aAdjusted for age, age at menarche, family history of breast cancer, number of children and ever use of hormone replacement therapy
  3. bAdjusted for study, age, age at menarche, family history of breast cancer, number of children and ever use of hormone replacement therapy