|  | KARMA | LIBRO1 | ||||
---|---|---|---|---|---|---|---|
Variables | Categories | Cases (n = 2272) | Controls (n = 10,468) | P value* | Cases (n = 4459) | Controls (n = 18237) | P value* |
Demographics | |||||||
 Age at questionnaire, years | Mean ± SD | 61.3 ± 9.2 | 55.7 ± 9.2 | <0.001 | 62.6 ± 9.7 | 57.4 ± 9.1 | <0.001 |
 Body size at age 7 years, n (%) | Small | 1327 (58.4) | 5644 (53.9) | <0.001 | 2727 (61.2) | 9870 (54.1) | <0.001 |
Medium | 773 (34.0) | 3824 (36.5) | 1358 (30.5) | 6622 (36.3) | |||
Large | 172 (7.6) | 1000 (9.6) | 374 (8.4) | 1745 (9.6) | |||
 Body size at age 18 years, n (%) | Small | 705 (31.0) | 3042 (29.1) | 0.001 | 1482 (33.3) | 5233 (28.7) | <0.001 |
Medium | 1407 (61.9) | 6433 (61.5) | 2638 (59.2) | 11,135 (61.1) | |||
Large | 160 (7.0) | 992 (9.5) | 334 (7.5) | 1866 (10.2) | |||
 BMI at questionnaire, kg/m2 | Mean ± SD | 25.6 ± 4.2 | 25.2 ± 4.1 | <0.001 | 25.3 ± 4.2 | 25.2 ± 4.2 | 0.071 |
Reproductive health factors | |||||||
 Age at menarche, years | Mean ± SD | 13.2 ± 1.5 | 13.2 ± 1.5 | 0.735 | 13.1 ± 1.5 | 13.1 ± 1.5 | 0.398 |
 Number of children, n (%) | Nulliparous | 407 (13.1) | 1574 (11.8) | 0.018 | 673 (15.1) | 2599 (14.3) | <0.001 |
1 | 502 (16.1) | 1910 (14.3) | 790 (17.7) | 2746 (15.1) | |||
2 | 1463 (46.9) | 6425 (48.2) | 1975 (44.3) | 8425 (46.2) | |||
≥3 | 743 (23.9) | 3430 (25.7) | 1021 (22.9) | 4467 (24.5) | |||
 Menopause status, n (%) | Postmenopause | 1999 (87.9) | 6733 (64.3) | <0.001 | 4229 (94.8) | 13,143 (72.1) | <0.001 |
Premenopause | 273 (12.0) | 3735 (35.7) | 230 (5.2) | 5094 (27.9) | |||
 Ever used HRT, n (%) | Yes | 882 (38.8) | 3025 (28.9) | <0.001 | 2381 (53.4) | 6225 (34.1) | <0.001 |
No | 1390 (61.2) | 7443 (71.1) | 2078 (46.6) | 12,012 (65.9) | |||
 Family history of breast cancer, n (%) | Yes | 487 (21.4) | 1431 (13.7) | <0.001 | 900 (20.2) | 2426 (13.3) | <0.001 |
No | 1785 (78.6) | 9037 (86.3) | 3559 (75.4) | 15,811 (86.7) |