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Fig. 2 | Breast Cancer Research

Fig. 2

From: Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis

Fig. 2

Cancer incidence and spectrum of tumors in K14Cre mice carrying conditional alleles of ERβ and p53. a Kaplan–Meier curves of tumor-free survival in K14CreERβ F/F p53 F/F (magenta; n = 15) and K14Crep53 F/F (dark magenta; n = 18) female mice. Median time of tumor-free survival (T 50) for K14Crep53 F/F females is 397 days and that for K14CreERβ F/F p53 F/F females is 333 days (P < 0.0001). Tumor types (mammary, skin or other) indicated for each mouse. b Kaplan–Meier mammary tumor-free K14CreERβ F/F 53 F/F (magenta; n = 11; T 50 = 335 days) and K14Crep53 F/F (dark magenta; n = 12, T 50 = 403 days) females (P = 0.00066). c Kaplan–Meier mammary tumor-free curve of K14Crep53 F/F female mice (dark magenta) vs K14CreERβ F/+ p53 F/F female mice (blue; n = 10; T 50 = 337 days; P = 0.06). d Mammary tumor-free mouse survival curves of K14Crep53 F/F (dark magenta), K14CreERβ F/F p53 F/F (magenta), K14CreERβ F/+ p53 F/F (blue) and ERβ F/F p53 F/F (green; n = 16) female mice. Mice were killed when mammary tumors reached a diameter of approximately 1 cm for mammary tumors or approximately 0.8 cm for skin tumors. ER estrogen receptor (Color figure online)

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