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Table 4 Groups of candidate genes related to a specific pathophysiological process, built to perform gene set enrichment analysis, and their respective references

From: The footprint of the ageing stroma in older patients with breast cancer

Gene group

Involved genes

References

Cellular senescence

CDKN1A, CDKN2A, TP53, RB1, GLB1

[17,18,19, 69,70,71]

DNA damage response

ATM, NBN, CHEK2

[21, 73]

Senescence-associated secretory profile

IL1A, IL6, IL6R, IL6ST, IL8, CXCL1, CXCL2, CXCL3, CSF2, IL7, ICAM1, TNFRSF11B, HGF, IGFBP4, CCL8, PLAUR, IGFBP2, CCL26, IL13, CCL20, ICAM3, PGF, TNFRSF1A, TNFRSF1B, CCL13, CCL16, TNFRSF10C, CCL2, FAS, ANG, IGFBP6, IL1B, (CCL3), TIMP2, IL11, OSM, LEP, AXL, KITLG, FGF7, IL15, FGF2, IGFBP1, MIF

[17, 21, 22, 26]

Autophagy-to-senescence transition

CAV1, CTSB, BNIP3, PRKAA1, PRKAA2, LAMP2, MAP1LC3B, ATG16L1, HIF1A, NFKB1, DRAM1, TP73, MAPK8, E2F1, STK11

[33,34,35,36,37]