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Table 4 Groups of candidate genes related to a specific pathophysiological process, built to perform gene set enrichment analysis, and their respective references

From: The footprint of the ageing stroma in older patients with breast cancer

Gene group Involved genes References
Cellular senescence CDKN1A, CDKN2A, TP53, RB1, GLB1 [17,18,19, 69,70,71]
DNA damage response ATM, NBN, CHEK2 [21, 73]
Senescence-associated secretory profile IL1A, IL6, IL6R, IL6ST, IL8, CXCL1, CXCL2, CXCL3, CSF2, IL7, ICAM1, TNFRSF11B, HGF, IGFBP4, CCL8, PLAUR, IGFBP2, CCL26, IL13, CCL20, ICAM3, PGF, TNFRSF1A, TNFRSF1B, CCL13, CCL16, TNFRSF10C, CCL2, FAS, ANG, IGFBP6, IL1B, (CCL3), TIMP2, IL11, OSM, LEP, AXL, KITLG, FGF7, IL15, FGF2, IGFBP1, MIF [17, 21, 22, 26]
Autophagy-to-senescence transition CAV1, CTSB, BNIP3, PRKAA1, PRKAA2, LAMP2, MAP1LC3B, ATG16L1, HIF1A, NFKB1, DRAM1, TP73, MAPK8, E2F1, STK11 [33,34,35,36,37]