From: The footprint of the ageing stroma in older patients with breast cancer
Gene group | Involved genes | References |
---|---|---|
Cellular senescence | CDKN1A, CDKN2A, TP53, RB1, GLB1 | |
DNA damage response | ATM, NBN, CHEK2 | |
Senescence-associated secretory profile | IL1A, IL6, IL6R, IL6ST, IL8, CXCL1, CXCL2, CXCL3, CSF2, IL7, ICAM1, TNFRSF11B, HGF, IGFBP4, CCL8, PLAUR, IGFBP2, CCL26, IL13, CCL20, ICAM3, PGF, TNFRSF1A, TNFRSF1B, CCL13, CCL16, TNFRSF10C, CCL2, FAS, ANG, IGFBP6, IL1B, (CCL3), TIMP2, IL11, OSM, LEP, AXL, KITLG, FGF7, IL15, FGF2, IGFBP1, MIF | |
Autophagy-to-senescence transition | CAV1, CTSB, BNIP3, PRKAA1, PRKAA2, LAMP2, MAP1LC3B, ATG16L1, HIF1A, NFKB1, DRAM1, TP73, MAPK8, E2F1, STK11 |