The footprint of the ageing stroma in older patients with breast cancer

Breast Cancer Research

Table 3 Significant up- or down-regulated genes after validation in the external validation data set (see Fig. 4)

Gene	Full name	Fold change
RARRES3	Retinoic acid receptor responder (tazarotene induced) 3	1.75
SFRP4	Secreted frizzled-related protein 4	1.71
SCUBE2	Signal peptide, CUB domain, EGF-like 2	1.83
NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)	1.51
COMP	Cartilage oligomeric matrix protein	1.56
ANXA3	Annexin A3	−2.06
PROM1	Prominin 1	−2.27
FGF13	Fibroblast growth factor 13	−1.68
TUBB2B	Tubulin, beta 2B	−1.64
WIF1	WNT inhibitory factor 1	−2.10

Negative values for fold change indicate up-regulation in old patient samples, and positive values indicate up-regulation in young patient samples

ISSN: 1465-542X