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Table 3 Significant up- or down-regulated genes after validation in the external validation data set (see Fig. 4)

From: The footprint of the ageing stroma in older patients with breast cancer

Gene Full name Fold change
RARRES3 Retinoic acid receptor responder (tazarotene induced) 3 1.75
SFRP4 Secreted frizzled-related protein 4 1.71
SCUBE2 Signal peptide, CUB domain, EGF-like 2 1.83
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 1.51
COMP Cartilage oligomeric matrix protein 1.56
ANXA3 Annexin A3 −2.06
PROM1 Prominin 1 −2.27
FGF13 Fibroblast growth factor 13 −1.68
TUBB2B Tubulin, beta 2B −1.64
WIF1 WNT inhibitory factor 1 −2.10
  1. Negative values for fold change indicate up-regulation in old patient samples, and positive values indicate up-regulation in young patient samples