The footprint of the ageing stroma in older patients with breast cancer

Brouwers, Barbara; Fumagalli, Debora; Brohee, Sylvain; Hatse, Sigrid; Govaere, Olivier; Floris, Giuseppe; Van den Eynde, Kathleen; Bareche, Yacine; Schöffski, Patrick; Smeets, Ann; Neven, Patrick; Lambrechts, Diether; Sotiriou, Christos; Wildiers, Hans

doi:10.1186/s13058-017-0871-0

Breast Cancer Research

Table 2 Genes with greater than 1.5-fold or less than −1.5-fold expression and respective fold changes

From: The footprint of the ageing stroma in older patients with breast cancer

Gene	Full name	Fold change
SPP1	Secreted phosphoprotein 1	−4.79
EPCAM	Epithelial cell adhesion molecule	−4.02
IL8	Interleukin 8	−2.74
NR4A2	Nuclear receptor subfamily 4, group A, member 2	−2.45
RGS2	Regulator of G-protein signaling 2, 24 kDa	−2.41
TREM1	Triggering receptor expressed on myeloid cells 1	−2.36
PROM1	Prominin 1	−2.27
SCG2	Secretogranin II	−2.22
LPL	Lipoprotein lipase	−2.20
SDC4	Syndecan 4	−2.19
SLC2A3	Solute carrier family 2 (facilitated glucose transporter), member 3	−2.13
PFKFB3	6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	−2.11
TNFRSF11B	Tumour necrosis factor receptor superfamily, member 11b	−2.11
WIF1	WNT inhibitory factor 1	−2.10
NAMPT	Nicotinamide phosphoribosyltransferase	−2.08
ENPEP	Glutamyl aminopeptidase (aminopeptidase A)	−2.07
ZNF331	Zinc finger protein 331	−2.07
ANXA3	Annexin A3	−2.06
HAPLN1	Hyaluronan and proteoglycan link protein 1	−2.05
CSN3	Casein kappa	−2.05
KRT23	Keratin 23 (histone deacetylase inducible)	−2.05
VEGFA	Vascular endothelial growth factor A	−2.03
STC1	Stanniocalcin 1	−2.01
EGLN3	Egl nine homolog 3 (C. elegans)	−1.97
ADM	Adrenomedullin	−1.96
G0S2	G0/G1 switch 2	−1.95
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	−1.93
TDO2	Tryptophan 2,3-dioxygenase	−1.93
CD24	CD24 molecule	−1.92
DNER	Delta/Notch-like epidermal growth factor-related receptor	−1.92
IBSP	Integrin-binding sialoprotein	−1.91
HSPA2	Heat shock 70 kDa protein 2	−1.90
ERRFI1	ERBB receptor feedback inhibitor 1	−1.89
MUCL1	Mucin-like 1	−1.89
APOLD1	Apolipoprotein L domain containing 1	−1.89
SHISA2	Shisa homolog 2 (Xenopus laevis)	−1.88
GPX3	Glutathione peroxidase 3 (plasma)	−1.87
SERPINE1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	−1.87
COL2A1	Collagen, type II, α 1	−1.86
CP	Ceruloplasmin (ferroxidase)	−1.85
COL9A3	Collagen, type IX, α 3	−1.85
ENO2	Enolase 2 (gamma, neuronal)	−1.84
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	−1.84
TSPAN13	Tetraspanin 13	−1.82
CYP4X1	Cytochrome P450, family 4, subfamily X, polypeptide 1	−1.82
TFAP2C	Transcription factor AP-2γ (activating enhancer binding protein 2γ)	−1.81
EGR3	Early growth response 3	−1.81
SOX11	SRY (sex-determining region Y), box 11	−1.79
CLEC5A	C-type lectin domain family 5, member A	−1.78
CYP26B1	Cytochrome P450, family 26, subfamily B, polypeptide 1	−1.78
SLPI	Secretory leukocyte peptidase inhibitor	−1.78
PI15	Peptidase inhibitor 15	−1.78
RBP7	Retinol binding protein 7, cellular	−1.77
SERPINA3	Serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 3	−1.77
CCDC102B	Coiled-coil domain containing 102B	−1.75
MTHFD2	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	−1.74
CFI	Complement factor I	−1.74
FCGBP	Fc fragment of IgG binding protein	−1.73
GPNMB	Glycoprotein (transmembrane) NMB	−1.73
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	−1.72
MAL2	Mal, T-cell differentiation protein 2	−1.72
UAP1	UDP-N-acteylglucosamine pyrophosphorylase 1	−1.71
IER3	Immediate early response 3	−1.70
COL4A1	Collagen, type IV, α 1	−1.69
EFNB2	Ephrin-B2	−1.69
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	−1.69
BTBD3	BTB (POZ) domain containing 3	−1.68
FGF13	Fibroblast growth factor 13	−1.68
GALNT3	UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	−1.67
INHBB	inhibin, β B	−1.66
MANSC1	MANSC domain containing 1	−1.65
DSP	Desmoplakin	−1.64
CLDN8	Claudin 8	−1.64
TUBB2B	Tubulin, β 2B	−1.64
PODXL	Podocalyxin-like	−1.63
EHF	ETS homologous factor	−1.63
TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	−1.63
ANGPT2	Angiopoietin 2	−1.62
ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	−1.62
GPR4	G protein-coupled receptor 4	−1.61
DBH	Dopamine β-hydroxylase (dopamine β-monooxygenase)	−1.61
GPR183	G protein-coupled receptor 183	−1.61
TFAP2A	Transcription factor AP-2 α (activating enhancer binding protein 2 α)	−1.60
SNORD89	Small nucleolar RNA, C/D box 89	−1.60
CXCL2	Chemokine (C-X-C motif) ligand 2	−1.60
CXADR	Coxsackie virus and adenovirus receptor	−1.60
TPRKB	TP53RK binding protein	−1.60
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	−1.60
RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	−1.60
ADGRF5	Adhesion G protein-coupled receptor F	−1.60
CA2	Carbonic anhydrase II	−1.59
LIPA	Lipase A, lysosomal acid, cholesterol esterase	−1.59
PGM2	Phosphoglucomutase 2	−1.59
KRT19	Keratin 19	−1.58
MGAT5	Mannosyl (α-1,6-)-glycoprotein β-1,6-N-acetyl-glucosaminyltransferase	−1.58
NCF2	Neutrophil cytosolic factor 2	−1.57
RHOU	Ras homolog gene family, member U	−1.57
ALCAM	Activated leukocyte cell adhesion molecule	−1.57
LRRN1	Leucine-rich repeat neuronal 1	−1.57
OLR1	Oxidized low-density lipoprotein (lectin-like) receptor 1	−1.55
SLC19A2	Solute carrier family 19 (thiamine transporter), member 2	−1.55
PRPS2	Phosphoribosyl pyrophosphate synthetase 2	−1.55
MEGF10	Multiple EGF-like domains 10	−1.55
CYYR1	Cysteine/tyrosine-rich 1	−1.54
PLVAP	Plasmalemma vesicle-associated protein	−1.54
TM4SF1	Transmembrane 4 L6 family member 1	−1.54
PDGFA	Platelet-derived growth factor α polypeptide	−1.54
YBX2	Y box binding protein 2	−1.54
ATP2B1	ATPase, Ca²⁺-transporting, plasma membrane 1	−1.54
PCDHB2	Protocadherin β 2	−1.54
DNMT1	DNA (cytosine-5-)-methyltransferase 1	−1.54
S100A8	S100 calcium binding protein A8	−1.53
MAP2	Microtubule-associated protein 2	−1.53
ARRDC4	Arrestin domain containing 4	−1.52
FAM83D	Family with sequence similarity 83, member D	−1.52
LSR	Lipolysis stimulated lipoprotein receptor	−1.52
STK26	Serine/threonine protein kinase 26	−1.51
MIR181A2HG	MIR181A2 host gene (non-protein coding)	−1.51
VWA8	von Willebrand factor A domain containing 8	−1.51
MEST	Mesoderm-specific transcript homolog (mouse)	−1.51
ZNF835	Zinc finger protein 835	1.51
NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)	1.51
EPSTI1	Epithelial stromal interaction 1 (breast)	1.51
LOC221946	Hypothetical LOC221946	1.51
OAS1	2′,5′-oligoadenylate synthetase 1, 40/46 kDa	1.52
SELL	Selectin L	1.52
COX6C	Cytochrome c oxidase subunit VIc	1.52
TRIM41	Tripartite motif-containing 41	1.52
IFI27	Interferon-α-inducible protein 27	1.52
IGF1	Insulin-like growth factor 1 (somatomedin C)	1.52
SCAMP1-AS1	SCAMP1 antisense RNA 1	1.52
CD207	CD207 molecule, langerin	1.52
IFI35	Interferon-induced protein 35	1.52
GGH	γ-Glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	1.52
NOX4	NADPH oxidase 4	1.53
CNTN3	Contactin 3 (plasmacytoma associated)	1.53
CCL5	Chemokine (C-C motif) ligand 5	1.54
GALNT1	UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)	1.54
SPON1	Spondin 1, extracellular matrix protein	1.54
SEMA3C	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	1.54
DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1.55
TNFSF10	Tumor necrosis factor (ligand) superfamily, member 10	1.55
CXCL14	Chemokine (C-X-C motif) ligand 14	1.55
WISP2	WNT1 inducible signaling pathway protein 2	1.55
STAT1	Signal transducer and activator of transcription 1, 91 kDa	1.55
COMP	Cartilage oligomeric matrix protein	1.56
IGLJ3	Immunoglobulin lambda joining 3	1.56
LRRC17	Leucine-rich repeat containing 17	1.56
IFI44	Interferon-induced protein 44	1.56
ISG15	ISG15 ubiquitin-like modifier	1.56
FBLN2	Fibulin 2	1.57
SLC6A6	Solute carrier family 6 (neurotransmitter transporter, taurine), member 6	1.57
MX2	Myxovirus (influenza virus) resistance 2 (mouse)	1.57
SH3D19	SH3 domain containing 19	1.57
TRBC1	T-cell receptor β constant 1	1.58
SGCE	Sarcoglycan, epsilon	1.58
IGHM	Immunoglobulin heavy constant mu	1.58
DCBLD1	Discoidin, CUB and LCCL domain containing 1	1.59
PPAPDC1A	Phosphatidic acid phosphatase type 2 domain containing 1A	1.59
BST2	Bone marrow stromal cell antigen 2	1.59
MFAP2	Microfibrillar-associated protein 2	1.60
PDGFD	Platelet-derived growth factor D	1.60
IGKC	Immunoglobulin kappa constant	1.60
CST1	Cystatin SN	1.61
CCL8	Chemokine (C-C motif) ligand 8	1.61
RASGRF2	Ras protein-specific guanine nucleotide-releasing factor 2	1.61
MX1	Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	1.63
PDGFRL	Platelet-derived growth factor receptor-like	1.63
ALDH1L2	Aldehyde dehydrogenase 1 family, member L2	1.63
FAM198B	Family with sequence similarity 198, member B	1.63
MIR100HG	Mir-100-let-7a-2 cluster host gene	1.64
GAPT	GRB2-binding adaptor protein, transmembrane	1.65
SELM	Selenoprotein M	1.65
DSCAM-AS1	DSCAM antisense RNA 1	1.66
STMN2	Stathmin-like 2	1.69
FBLN5	Fibulin 5	1.70
IFIT3	Interferon-induced protein with tetratricopeptide repeats 3	1.70
SFRP4	Secreted frizzled-related protein 4	1.71
ACKR4	Atypical chemokine receptor 4	1.71
CPNE2	Copine II	1.71
PSMB9	Proteasome (prosome, macropain) subunit, β type, 9 (large multifunctional peptidase 2)	1.72
ST6GAL2	ST6 β-galactosamide α-2,6-sialyltranferase 2	1.72
NEXN	Nexilin (F actin binding protein)	1.72
CD52	CD52 molecule	1.72
MFAP5	Microfibrillar associated protein 5	1.73
RARRES3	Retinoic acid receptor responder (tazarotene induced) 3	1.75
GXYLT2	Glucoside xylosyltransferase 2	1.75
HMCN1	Hemicentin 1	1.76
EFEMP1	EGF-containing fibulin-like extracellular matrix protein 1	1.78
IL21R	Interleukin 21 receptor	1.78
C8orf4	Chromosome 8 open reading frame 4	1.78
LINC01503	Long intergenic non-protein coding RNA 1503	1.78
OLFML3	Olfactomedin-like 3	1.79
CILP	Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	1.81
MVB12A	Multivesicular body subunit 12A	1.82
SCUBE2	Signal peptide, CUB domain, EGF-like 2	1.83
WNT2	Wingless-type MMTV integration site family member 2	1.85
APOL3	Apolipoprotein L3	1.87
ADRA2A	Alpha-2A adrenergic receptor	1.89
HIST1H3I	Histone cluster 1, H3i	1.92
SLC46A3	Solute carrier family 46, member 3	1.92
ARHGAP28	Rho GTPase activating protein 28	1.93
KANK4	KN motif and ankyrin repeat domains 4	1.93
SDC1	Syndecan 1	1.95
CMPK2	Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	1.96
IFI44L	Interferon-induced protein 44-like	1.97
FMO1	Flavin containing monooxygenase 1	1.98
TMEM119	Transmembrane protein 119	1.99
FNDC1	Fibronectin type III domain containing 1	2.00
ADAMDEC1	ADAM-like, decysin 1	2.00
TPSAB1	Tryptase α/β1	2.02
CPA3	Carboxypeptidase A3 (mast cell)	2.02
MMP3	Matrix metallopeptidase 3 (stromelysin 1, progelatinase)	2.05
IFI6	Interferon, α-inducible protein 6	2.06
IFIT1	Interferon-induced protein with tetratricopeptide repeats 1	2.06
SFRP2	Secreted frizzled-related protein 2	2.09
TRIM6	Tripartite motif-containing 6	2.10
TPSB2	Tryptase β2 (gene/pseudogene)	2.19
RSAD2	Radical S-adenosyl methionine domain containing 2	2.28
LOXL1	Lysyl oxidase-like 1	2.30
OMD	Osteomodulin	2.35
IGJ	Immunoglobulin J polypeptide, linker protein for immunoglobulin α and mu polypeptides	2.44
FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64)	2.47
MATN3	Matrilin 3	2.55
IGLV@	Immunoglobulin lambda variable cluster	2.65
OGN	Osteoglycin	2.99
EPYC	Epiphycan	3.04

Negative values for fold change indicate up-regulation in older patient samples; positive fold change values indicate up-regulation in younger patient samples

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ISSN: 1465-542X

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