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Table 2 Genes with greater than 1.5-fold or less than −1.5-fold expression and respective fold changes

From: The footprint of the ageing stroma in older patients with breast cancer

Gene Full name Fold change
SPP1 Secreted phosphoprotein 1 −4.79
EPCAM Epithelial cell adhesion molecule −4.02
IL8 Interleukin 8 −2.74
NR4A2 Nuclear receptor subfamily 4, group A, member 2 −2.45
RGS2 Regulator of G-protein signaling 2, 24 kDa −2.41
TREM1 Triggering receptor expressed on myeloid cells 1 −2.36
PROM1 Prominin 1 −2.27
SCG2 Secretogranin II −2.22
LPL Lipoprotein lipase −2.20
SDC4 Syndecan 4 −2.19
SLC2A3 Solute carrier family 2 (facilitated glucose transporter), member 3 −2.13
PFKFB3 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 −2.11
TNFRSF11B Tumour necrosis factor receptor superfamily, member 11b −2.11
WIF1 WNT inhibitory factor 1 −2.10
NAMPT Nicotinamide phosphoribosyltransferase −2.08
ENPEP Glutamyl aminopeptidase (aminopeptidase A) −2.07
ZNF331 Zinc finger protein 331 −2.07
ANXA3 Annexin A3 −2.06
HAPLN1 Hyaluronan and proteoglycan link protein 1 −2.05
CSN3 Casein kappa −2.05
KRT23 Keratin 23 (histone deacetylase inducible) −2.05
VEGFA Vascular endothelial growth factor A −2.03
STC1 Stanniocalcin 1 −2.01
EGLN3 Egl nine homolog 3 (C. elegans) −1.97
ADM Adrenomedullin −1.96
G0S2 G0/G1 switch 2 −1.95
BAMBI BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) −1.93
TDO2 Tryptophan 2,3-dioxygenase −1.93
CD24 CD24 molecule −1.92
DNER Delta/Notch-like epidermal growth factor-related receptor −1.92
IBSP Integrin-binding sialoprotein −1.91
HSPA2 Heat shock 70 kDa protein 2 −1.90
ERRFI1 ERBB receptor feedback inhibitor 1 −1.89
MUCL1 Mucin-like 1 −1.89
APOLD1 Apolipoprotein L domain containing 1 −1.89
SHISA2 Shisa homolog 2 (Xenopus laevis) −1.88
GPX3 Glutathione peroxidase 3 (plasma) −1.87
SERPINE1 Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 −1.87
COL2A1 Collagen, type II, α 1 −1.86
CP Ceruloplasmin (ferroxidase) −1.85
COL9A3 Collagen, type IX, α 3 −1.85
ENO2 Enolase 2 (gamma, neuronal) −1.84
FOSB FBJ murine osteosarcoma viral oncogene homolog B −1.84
TSPAN13 Tetraspanin 13 −1.82
CYP4X1 Cytochrome P450, family 4, subfamily X, polypeptide 1 −1.82
TFAP2C Transcription factor AP-2γ (activating enhancer binding protein 2γ) −1.81
EGR3 Early growth response 3 −1.81
SOX11 SRY (sex-determining region Y), box 11 −1.79
CLEC5A C-type lectin domain family 5, member A −1.78
CYP26B1 Cytochrome P450, family 26, subfamily B, polypeptide 1 −1.78
SLPI Secretory leukocyte peptidase inhibitor −1.78
PI15 Peptidase inhibitor 15 −1.78
RBP7 Retinol binding protein 7, cellular −1.77
SERPINA3 Serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 3 −1.77
CCDC102B Coiled-coil domain containing 102B −1.75
MTHFD2 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase −1.74
CFI Complement factor I −1.74
FCGBP Fc fragment of IgG binding protein −1.73
GPNMB Glycoprotein (transmembrane) NMB −1.73
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) −1.72
MAL2 Mal, T-cell differentiation protein 2 −1.72
UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1 −1.71
IER3 Immediate early response 3 −1.70
COL4A1 Collagen, type IV, α 1 −1.69
EFNB2 Ephrin-B2 −1.69
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) −1.69
BTBD3 BTB (POZ) domain containing 3 −1.68
FGF13 Fibroblast growth factor 13 −1.68
GALNT3 UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) −1.67
INHBB inhibin, β B −1.66
MANSC1 MANSC domain containing 1 −1.65
DSP Desmoplakin −1.64
CLDN8 Claudin 8 −1.64
TUBB2B Tubulin, β 2B −1.64
PODXL Podocalyxin-like −1.63
EHF ETS homologous factor −1.63
TIPARP TCDD-inducible poly(ADP-ribose) polymerase −1.63
ANGPT2 Angiopoietin 2 −1.62
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 −1.62
GPR4 G protein-coupled receptor 4 −1.61
DBH Dopamine β-hydroxylase (dopamine β-monooxygenase) −1.61
GPR183 G protein-coupled receptor 183 −1.61
TFAP2A Transcription factor AP-2 α (activating enhancer binding protein 2 α) −1.60
SNORD89 Small nucleolar RNA, C/D box 89 −1.60
CXCL2 Chemokine (C-X-C motif) ligand 2 −1.60
CXADR Coxsackie virus and adenovirus receptor −1.60
TPRKB TP53RK binding protein −1.60
ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) −1.60
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 −1.60
ADGRF5 Adhesion G protein-coupled receptor F −1.60
CA2 Carbonic anhydrase II −1.59
LIPA Lipase A, lysosomal acid, cholesterol esterase −1.59
PGM2 Phosphoglucomutase 2 −1.59
KRT19 Keratin 19 −1.58
MGAT5 Mannosyl (α-1,6-)-glycoprotein β-1,6-N-acetyl-glucosaminyltransferase −1.58
NCF2 Neutrophil cytosolic factor 2 −1.57
RHOU Ras homolog gene family, member U −1.57
ALCAM Activated leukocyte cell adhesion molecule −1.57
LRRN1 Leucine-rich repeat neuronal 1 −1.57
OLR1 Oxidized low-density lipoprotein (lectin-like) receptor 1 −1.55
SLC19A2 Solute carrier family 19 (thiamine transporter), member 2 −1.55
PRPS2 Phosphoribosyl pyrophosphate synthetase 2 −1.55
MEGF10 Multiple EGF-like domains 10 −1.55
CYYR1 Cysteine/tyrosine-rich 1 −1.54
PLVAP Plasmalemma vesicle-associated protein −1.54
TM4SF1 Transmembrane 4 L6 family member 1 −1.54
PDGFA Platelet-derived growth factor α polypeptide −1.54
YBX2 Y box binding protein 2 −1.54
ATP2B1 ATPase, Ca2+-transporting, plasma membrane 1 −1.54
PCDHB2 Protocadherin β 2 −1.54
DNMT1 DNA (cytosine-5-)-methyltransferase 1 −1.54
S100A8 S100 calcium binding protein A8 −1.53
MAP2 Microtubule-associated protein 2 −1.53
ARRDC4 Arrestin domain containing 4 −1.52
FAM83D Family with sequence similarity 83, member D −1.52
LSR Lipolysis stimulated lipoprotein receptor −1.52
STK26 Serine/threonine protein kinase 26 −1.51
MIR181A2HG MIR181A2 host gene (non-protein coding) −1.51
VWA8 von Willebrand factor A domain containing 8 −1.51
MEST Mesoderm-specific transcript homolog (mouse) −1.51
ZNF835 Zinc finger protein 835 1.51
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 1.51
EPSTI1 Epithelial stromal interaction 1 (breast) 1.51
LOC221946 Hypothetical LOC221946 1.51
OAS1 2′,5′-oligoadenylate synthetase 1, 40/46 kDa 1.52
SELL Selectin L 1.52
COX6C Cytochrome c oxidase subunit VIc 1.52
TRIM41 Tripartite motif-containing 41 1.52
IFI27 Interferon-α-inducible protein 27 1.52
IGF1 Insulin-like growth factor 1 (somatomedin C) 1.52
SCAMP1-AS1 SCAMP1 antisense RNA 1 1.52
CD207 CD207 molecule, langerin 1.52
IFI35 Interferon-induced protein 35 1.52
GGH γ-Glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 1.52
NOX4 NADPH oxidase 4 1.53
CNTN3 Contactin 3 (plasmacytoma associated) 1.53
CCL5 Chemokine (C-C motif) ligand 5 1.54
GALNT1 UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) 1.54
SPON1 Spondin 1, extracellular matrix protein 1.54
SEMA3C Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 1.54
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 1.55
TNFSF10 Tumor necrosis factor (ligand) superfamily, member 10 1.55
CXCL14 Chemokine (C-X-C motif) ligand 14 1.55
WISP2 WNT1 inducible signaling pathway protein 2 1.55
STAT1 Signal transducer and activator of transcription 1, 91 kDa 1.55
COMP Cartilage oligomeric matrix protein 1.56
IGLJ3 Immunoglobulin lambda joining 3 1.56
LRRC17 Leucine-rich repeat containing 17 1.56
IFI44 Interferon-induced protein 44 1.56
ISG15 ISG15 ubiquitin-like modifier 1.56
FBLN2 Fibulin 2 1.57
SLC6A6 Solute carrier family 6 (neurotransmitter transporter, taurine), member 6 1.57
MX2 Myxovirus (influenza virus) resistance 2 (mouse) 1.57
SH3D19 SH3 domain containing 19 1.57
TRBC1 T-cell receptor β constant 1 1.58
SGCE Sarcoglycan, epsilon 1.58
IGHM Immunoglobulin heavy constant mu 1.58
DCBLD1 Discoidin, CUB and LCCL domain containing 1 1.59
PPAPDC1A Phosphatidic acid phosphatase type 2 domain containing 1A 1.59
BST2 Bone marrow stromal cell antigen 2 1.59
MFAP2 Microfibrillar-associated protein 2 1.60
PDGFD Platelet-derived growth factor D 1.60
IGKC Immunoglobulin kappa constant 1.60
CST1 Cystatin SN 1.61
CCL8 Chemokine (C-C motif) ligand 8 1.61
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 1.61
MX1 Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) 1.63
PDGFRL Platelet-derived growth factor receptor-like 1.63
ALDH1L2 Aldehyde dehydrogenase 1 family, member L2 1.63
FAM198B Family with sequence similarity 198, member B 1.63
MIR100HG Mir-100-let-7a-2 cluster host gene 1.64
GAPT GRB2-binding adaptor protein, transmembrane 1.65
SELM Selenoprotein M 1.65
DSCAM-AS1 DSCAM antisense RNA 1 1.66
STMN2 Stathmin-like 2 1.69
FBLN5 Fibulin 5 1.70
IFIT3 Interferon-induced protein with tetratricopeptide repeats 3 1.70
SFRP4 Secreted frizzled-related protein 4 1.71
ACKR4 Atypical chemokine receptor 4 1.71
CPNE2 Copine II 1.71
PSMB9 Proteasome (prosome, macropain) subunit, β type, 9 (large multifunctional peptidase 2) 1.72
ST6GAL2 ST6 β-galactosamide α-2,6-sialyltranferase 2 1.72
NEXN Nexilin (F actin binding protein) 1.72
CD52 CD52 molecule 1.72
MFAP5 Microfibrillar associated protein 5 1.73
RARRES3 Retinoic acid receptor responder (tazarotene induced) 3 1.75
GXYLT2 Glucoside xylosyltransferase 2 1.75
HMCN1 Hemicentin 1 1.76
EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 1.78
IL21R Interleukin 21 receptor 1.78
C8orf4 Chromosome 8 open reading frame 4 1.78
LINC01503 Long intergenic non-protein coding RNA 1503 1.78
OLFML3 Olfactomedin-like 3 1.79
CILP Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 1.81
MVB12A Multivesicular body subunit 12A 1.82
SCUBE2 Signal peptide, CUB domain, EGF-like 2 1.83
WNT2 Wingless-type MMTV integration site family member 2 1.85
APOL3 Apolipoprotein L3 1.87
ADRA2A Alpha-2A adrenergic receptor 1.89
HIST1H3I Histone cluster 1, H3i 1.92
SLC46A3 Solute carrier family 46, member 3 1.92
ARHGAP28 Rho GTPase activating protein 28 1.93
KANK4 KN motif and ankyrin repeat domains 4 1.93
SDC1 Syndecan 1 1.95
CMPK2 Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 1.96
IFI44L Interferon-induced protein 44-like 1.97
FMO1 Flavin containing monooxygenase 1 1.98
TMEM119 Transmembrane protein 119 1.99
FNDC1 Fibronectin type III domain containing 1 2.00
ADAMDEC1 ADAM-like, decysin 1 2.00
TPSAB1 Tryptase α/β1 2.02
CPA3 Carboxypeptidase A3 (mast cell) 2.02
MMP3 Matrix metallopeptidase 3 (stromelysin 1, progelatinase) 2.05
IFI6 Interferon, α-inducible protein 6 2.06
IFIT1 Interferon-induced protein with tetratricopeptide repeats 1 2.06
SFRP2 Secreted frizzled-related protein 2 2.09
TRIM6 Tripartite motif-containing 6 2.10
TPSB2 Tryptase β2 (gene/pseudogene) 2.19
RSAD2 Radical S-adenosyl methionine domain containing 2 2.28
LOXL1 Lysyl oxidase-like 1 2.30
OMD Osteomodulin 2.35
IGJ Immunoglobulin J polypeptide, linker protein for immunoglobulin α and mu polypeptides 2.44
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2.47
MATN3 Matrilin 3 2.55
IGLV@ Immunoglobulin lambda variable cluster 2.65
OGN Osteoglycin 2.99
EPYC Epiphycan 3.04
  1. Negative values for fold change indicate up-regulation in older patient samples; positive fold change values indicate up-regulation in younger patient samples