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Fig. 4 | Breast Cancer Research

Fig. 4

From: Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice

Fig. 4

Differentially expressed genes (DEGs) in mammary glands of F1 and F3 generation offspring of dams fed either control (CON) or high-fat (HF) diet during pregnancy. a RNA-sequencing analysis identified 1587 DEGs in F1 and 4423 DEGs in F3 generation mammary glands obtained on postnatal day 100 from mice not exposed to 7,12-dimethylbenz[a]anthracene (n = 5 CON and n = 3 HF offspring in F1 generation, and n = 4 CON and n = 5 HF offspring in F3 generation). A total of 390 common DEGs were found in the F1 and F3 generations, with 48 regulated in the same direction in both generations. Heat map of common 48 DEGs in (b) F1 mammary glands and (c) F3 mammary glands. Knowledge-fused differential dependency networks cluster map of nodes uniquely connected to different sets of genes in HF or CON offspring in (d) F1 or (e) F3 generation. Yellow ovals indicate nodes. Single-lined green connections indicate gene interactions in HF offspring. Double-lined red connections indicate gene interaction in CON offspring

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