Fig. 2

Specific microRNAs (miRNAs) altered in patients with triple-negative breast cancer (TNBC) with lung metastases. a Hierarchical clustering represented in the heat map clearly discriminated normal breast tissues from tumors. Samples are presented in columns, and differently expressed miRNAs are presented in rows. Colored bars show the range of normalized log₂ signals. b and c Venn diagram and the corresponding table describing the expression patterns of miRNAs dysregulated in patients with lung metastases and recurrence-free patients. Three miRNAs were overexpressed regardless of prognosis. Eight miRNAs were dysregulated in both metastatic (Met) and primary tumors (Tumor) in the lung metastasis group, especially miR-629-3p, which was the most upregulated (P < 0.001)