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Table 2 Univariate and multivariate analysis of S100A7 expression

From: Interaction with adipocyte stromal cells induces breast cancer malignancy via S100A7 upregulation in breast cancer microenvironment

Clinical parameters

Univariate

Multivariate

P value

Relative risk (95% CI)

P value

Relative risk (95% CI)

Relapse-free survival

 Ki-67 LI (≥15%/<15%)

<0.0001

7.3 (3.0–21.7)

0.0004

5.7 (2.1–18.1)

 S100A7 status (+/−)

0.0005

3.8 (1.8–8.4)

0.0227

2.5 (1.1– 5.9)

 Lymph node metastasis (+/−)

0.0006

3.6 (1.7–8.0)

0.0150

2.8 (1.2–6.6)

 Histological Grade (3/1, 2)

0.0357

2.3 (1.1–4.8)

  

 HER2 status (+/−)

0.0861

   

 ER status (−/+)

0.0998

   

 Menopausal Status (pre/post)

0.4209

   

Breast cancer survival

 Ki-67 LI (≥15%/<15%)

0.0009

13.0 (2.5–239.2)

0.0346

7.5 (1.1–150.8)

 Lymph node metastasis (+/−)

0.0098

5.1 (1.5–23.1)

  

 S100A7 status (+/−)

0.0124

4.7 (1.4–18.1)

  

 Histological Grade (3/1,2)

0.0127

4.6 (1.4–17.6)

  

 ER status (+/−)

0.1371

   

 Menopausal Status (pre/post)

0.3919

   

 HER2 status (+/−)

0.6477

   
  1. Data considered significant (P < 0.05) are shown in boldface type. Parameters with significant values were further examined in the multivariate analysis. Relative risks of only significant values are shown
  2. Abbreviations: ER, Estrogen receptor, HER2 Human epidermal growth factor receptor 2, LI Labeling index
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Breast Cancer Research

ISSN: 1465-542X

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