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Fig. 3 | Breast Cancer Research

Fig. 3

From: Interaction with adipocyte stromal cells induces breast cancer malignancy via S100A7 upregulation in breast cancer microenvironment

Fig. 3

S100A7 expression knockdown significantly decreased adipose stromal cell (ASC)-derived factors induced proliferation and migration rate in breast carcinoma cells. a S100A7 and receptor for advanced glycation endproducts (RAGE) protein expression levels were significantly reduced by 5 nM small interfering RNA (siRNA) treatment after 72 h. Knockdown of S100A7 expression suppressed adipose stromal cell-derived conditioned medium (ACM) or adipocyte coculture induced (b) proliferation and (c) migration rate in MCF7, SK-BR-3, T47D, and ZR-75-1 cells. siN Negative control small interfering RNA, siS S100A7 small interfering RNA, ctrl Control, Mono Monoculture, +3t3a Coculture with 3T3-L1 adipose stromal cells. * P < 0.05 compared with siN + ACM/3T3a; ** P < 0.0001 compared with control

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Breast Cancer Research

ISSN: 1465-542X

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