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Table 1 Sensitivity and specificity for detecting BRCA1-like status samples using BRCA1ness

From: The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting

  MLPA BRCA1-like MLPA non-BRCA1-like
BRCA1ness positive 59 18
BRCA1ness negative 2 49
  Sensitivity Specificity
96.7% 73.1%
  1. MLPA multiplex ligation-dependent probe amplification