Fig. 4

I-SPY 2 TRIAL. a Mosaic plot depicting the number of patients with pathological complete response (pCR) in each treatment group and signature group. Top row indicates patients in the trial enrolled in the control arm and bottom row indicates patients in the V-C arm. Number of patients with pCR is shown in green and number of patients without pCR is shown in tan. Black outlined boxes indicate the patients with a non-BRCA1ness status (left), red outlined boxes depict those with BRCA1ness status (right). b Histological subtype of the patients in the trial divided by treatment arm (V-C) and control arm and pCR rate per group. c Odds ratio (OR) and likelihood ratio test (LR) for treatment and control arms of the trial and the biomarker x treatment interaction test. HER2 human epidermal growth factor receptor 2, HR hormone receptor status, TN triple-negative, V/C veliparib-carboplatin (Color figure online)