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Fig. 2 | Breast Cancer Research

Fig. 2

From: The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting

Fig. 2

Unsupervised hierarchical clustering of 77 genes in the 128 discovery set samples. The 77 genes were derived from a supervised analysis to identify those genes most informative in distinguishing BRCA1-like from non-BRCA1-like TN breast cancers [33]. Scaled expression value denoted as Z score (red–blue scale: red indicates high expression and blue indicates low expression). Information bar indicates MLPA BRCA1-like status: true (green) or false (brown). MLPA multiplex ligation-dependent probe amplification (Color figure online)

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