Fig. 9

Survival rates in breast cancer patients with high expression of myocardin-related transcription factor (MRTF)-A and its target genes. Microarray mRNA expression datasets of Clynes [24] and Bertucci [25] were analyzed using the R2 microarray and visualization platform software. a Kaplan–Meier plots for 96 months of follow up of 104 patients with mixed types of breast cancer (Clynes) or a luminal A/B subset of patients with medullary breast cancer (n = 129; Bertucci), using the p value scanning method. Relative hazard ratios (HR) for high MRTF-A expression (blue lines) were calculated following age adjustment and Cox regression analysis. Dashes indicate censored patients. b Five-year survival probability in patients with low or high expression of the MRTF target genes ACTA2, TAGLN, ITGA5 and CTGF. Data were extracted from Kaplan–Meier graphs of the datasets indicated: p values were calculated for significant differences, using the log-rank test