Table 4 Association between mammographic measures and screen-detected breast cancer risk - Lunn and McNeil

 VDG1

46/46,089

ref

NA

ref

 VDG2

143/99,086

1.49 (1.07 ; 2.07)

NA

1.53 (1.07 ; 2.21)

 VDG3

89/73,207

1.43 (0.99 ; 2.05)

NA

1.41 (0.94 ; 2.10)

 VDG4

21/20,314

1.39 (0.82 ; 2.36)

NA

1.41 (0.79 ; 2.54)

P trend

0.147

0.219

 Q1 (<4.8%)

63/58,411

ref

NA

ref

 Q2 (4.8–6.4%)

82/61,153

1.27 (0.91 ; 1.76)

NA

1.27 (0.89 ; 1.81)

 Q3 (6.4–9.8%)

86/60,499

1.47 (1.06 ; 2.04)

NA

1.52 (1.06 ; 2.17)

 Q4 (>9.8%)

68/58,633

1.36 (0.97 ; 1.94)

NA

1.27 (0.86 ; 1.89)

P trend

0.049

0.119

Percent dense volume (per SD increase)^#

299/238,696

1.10 (0.97 ; 1.25)

NA

1.08 (0.94 ; 1.24)

 C1 (<39.8 cm³)

38/45,851

ref

ref

ref

 C2 (39.9–65.2 cm³)

123/96,827

1.55 (1.08 ; 2.23)

1.52 (1.03 ; 2.23)

1.76 (1.14 ; 2.72)

 C3 (65.3–110.1 cm³)

101/74,190

1.76 (1.21 ; 2.56)

1.69 (1.11 ; 2.57)

1.99 (1.24 ; 3.17)

 C4 (>110.1 cm³)

37/21,828

2.40 (1.52 ; 3.79)

2.30 (1.39 ; 3.80)

2.03 (1.13 ; 3.67)

P trend

<0.001

0.002

0.014

 Q1 (<42.9 cm³)

48/57,909

ref

ref

ref

 Q2 (42.9–57.8 cm³)

71/59,364

1.46 (1.01 ; 2.10)

1.45 (0.99 ; 2.13)

1.62 (1.06 ; 2.48)

 Q3 (57.9–78.9 cm³)

80/60,359

1.67 (1.16 ; 2.39)

1.67 (1.13 ; 2.47)

1.86 (1.21 ; 2.87)

 Q4 (>78.9 cm³)

100/61,065

2.22 (1.57 ; 3.14)

2.24 (1.51 ; 3.31)

2.31 (1.49 ; 3.58)

P trend

<0.001

<0.001

<0.001

Dense volume (per SD increase)^#

299/238,696

1.27 (1.14 ; 1.43)

1.27 (1.11 ; 1.45)

1.22 (1.05 ; 1.41)