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Table 9 Correlation between age and cumulative methylation index for BRCA1/2 methylation

From: BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers

Age CMI for BRCA1 CMI for BRCA2 CMI for BRCA1 + BRCA2
Spearman’s rho p Value Spearman’s rho p Value Spearman’s rho p Value
BRCA1-C −0.297 0.066 −0.287 0.077 −0.275 0.090
BRCA2-C −0.019 0.918 0.003 0.989 −0.035 0.846
Sporadic-C −0.153 0.175 0.003 0.982 −0.120 0.289
BRCA1/2-N −0.252 0.513 −0.467 0.205 −0.417 0.265
Non-BRCA-related-N 0.300 0.624 0.100 0.873 0.100 0.873
  1. Abbreviations: BRCA1/2 BRCA1 and BRCA2, BRCA1-C Breast carcinomas from BRCA1 germline mutation carriers, BRCA2-C Breast carcinomas from BRCA2 germline mutation carriers, BRCA1/2-N Normal breast tissue from BRCA1 and BRCA2 germline mutation carriers, CMI Cumulative methylation index, Non-BRCA-related-N Normal breast tissue from patients not known to have a BRCA1 or BRCA2 germline mutation, Sporadic-C Sporadic breast carcinoma
  2. Correlation between age and CMI measured by Spearman’s rho correlation coefficient. CMI is calculated as the sum of the methylation percentage of all BRCA1 or BRCA2 methylation probes