BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers

Breast Cancer Research

Table 8 Relationship between BRCA1/2 methylation and clinicopathological variables in BRCA2-related carcinomas

BRCA2-related carcinomas	Grades 1–2 vs. 3		Ductal vs. lobular tumors		ER-positive vs. ER-negative		PR-positive vs. PR-negative		HER2-positive vs. HER2-negative
Probe	Test statistic^a	p Value	Test statistic^a	p Value	Test statistic^a	p Value	Test statistic^a	p Value	Test statistic^a	p Value
BRCA1.1	1.065^b	0.542	0.147^b	1.000	0.769^b	0.432	0.002^b	1.000	0.067^b	1.000
BRCA1.2	0.062^b	1.000	0.057^b	1.000	0.248^b	0.695	0.730^c	0.491	0.760^b	1.000
BRCA1.3	1.065^b	0.542	0.147^b	1.000	0.769^b	0.432	0.002^b	1.000	0.067^b	1.000
BRCA1 total^c	0.062^b	1.000	0.057^b	1.000	0.248^b	0.695	0.730^bb	0.491	0.760^b	1.000
BRCA2.1	2.200^c	0.266	0.002^b	1.000	0.088^b	1.000	2.528^c	0.166	1.238^b	0.455
BRCA2.2	1.650^b	0.534	0.229^b	1.000	0.149^b	1.000	0.437^b	0.601	0.103^b	1.000
BRCA2.3	3.039^b	0.136	0.115^b	1.000	1.742^b	0.238	0.022^c	1.000	0.760^b	1.000
BRCA2.4	0.569^b	0.586	0.317^b	1.000	0.001^b	1.000	0.004^b	1.000	0.142^b	1.000
BRCA2 total^c	3.110^b	0.132	0.057^b	1.000	0.916^b	0.431	0.863^c	0.481	1.587^b	0.394

Abbreviations: BRCA1/2 BRCA1 and BRCA2, ER Estrogen receptor, ER Estrogen receptor, HER2 Human epidermal growth factor receptor 2, PR Progesterone receptor
^aPearson’s chi-square test or Fisher’s exact test
^cPearson’s chi-square test
^bFisher’s exact test

ISSN: 1465-542X