Table 5 Sensitivity and specificity for each methylation probe in distinguishing BRCA1/2-related from sporadic breast carcinomas

BRCA1.1^a

70 of 72 (97.2%)

90.3–99.6%

11 of 80 (13.8%)

7.1–23.3%

BRCA1.2^b

46 of 72 (63.9%)

51.7–74.9%

58 of 80 (72.5%)

61.4–81.9%

BRCA1.3^a

65 of 72 (90.3%)

90.0–96.0%

11 of 80 (13.8%)

7.1–23.3%

BRCA1 total^c

46 of 72 (63.9%)

51.7–74.9%

58 of 80 (72.5%)

61.4–81.9%

BRCA2.1^b

48 of 72 (66.7%

54.6–77.3%

70 of 80 (87.5%)

78.2–93.8%

BRCA2.2^b

7 of 72 (9.7%)

4.0–19.0%

80 of 80 (100%)

95.5–100%

BRCA2.3^b

36 of 72 (50.0%)

38.0–62.0%

78 of 80 (97.5%)

91.3–99.7%

BRCA2.4^b

7 of 72 (9.7%)

4.0–19.0%

80 of 80 (100%)

95.5–100%

BRCA2 total^c

50 of 72 (69.4%)

57.5–79.8%

70 of 80 (87.5%)

78.2–93.8%