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Table 1 Clinicopathological characteristics of included breast samples

From: BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers

 

BRCA1-C

BRCA2-C

Sporadic-C

BRCA1-N

BRCA2-N

Non-BRCA- related-N

p ValueA

n

%

n

%

n

%

n

%

n

%

n

%

Number of samples (%)

39

23.5

33

19.9

80

48.2

5

3

4

2.4

5

3

 

Age, years

         

9.56°10−9*ǂ

 Median

43

N/A

46

N/A

58

N/A

31

N/A

36.5

N/A

22

N/A

0.549B

 Range

30–80

N/A

21–69

N/A

29–86

N/A

29–33

N/A

35–38

N/A

18–52

N/A

 

GradeC

         

0.00007*Ç‚Ç‚

 1

0

0

1

3

20

25.3

    

 2

9

23.1

10

30.3

25

31.6

    

 3

30

76.9

22

66.7

34

43

    

Tumor type

         

0.230Ç‚Ç‚

 Ductal

34

87.2

29

87.9

69

86.3

    

 Lobular

2

5.1

2

6.1

10

12.5

    

 Other

3

7.7

2

6.1

1

1.3

    

ER

         

0.0004*Ç‚Ç‚Ç‚

 Negative

26

66.7

8

24.2

23

28.8

    

 Positive

13

33.3

25

75.8

57

71.3

    

PR

         

0.001*Ç‚Ç‚Ç‚

 Negative

29

74.4

17

51.5

30

37.5

    

 Positive

10

25.6

16

48.5

50

62.5

    

HER2

         

0.68Ç‚Ç‚

 Negative

38

97.4

32

97

75

93.8

    

 Positive

1

2.6

1

3

5

6.3

    
  1. Abbreviations: BRCA1-C Breast carcinomas from BRCA1 germline mutation carriers, BRCA2-C Breast carcinomas from BRCA2 germline mutation carriers, BRCA1/2-N Normal breast tissue from BRCA1 and BRCA2 germline mutation carriers, ER Estrogen receptor, Non-BRCA-related-N Normal breast tissue from patients not known to have a BRCA1 or BRCA2 germline mutation, HER2 Human epidermal growth factor receptor 2, N/A Not available, PR Progesterone receptor, Sporadic-C Sporadic breast carcinoma
  2. ATesting BRCA1-C and BRCA2-C together against Sporadic-C
  3. BTesting BRCA1-N and BRCA2-N together against non-BRCA-related N
  4. CFor 1 of 80 sporadic breast cancer cases, the grade was unknown
  5. Ç‚Mann-Whitney U test
  6. ǂǂFisher’s exact test
  7. ǂǂǂPearson’s chi-square test
  8. *Statistically significant (two-sided p value <0.05)