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Fig. 2 | Breast Cancer Research

Fig. 2

From: A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data

Fig. 2

Distribution of pathogenic and truncating variants on breast cancer genes in our case dataset of 673 breast cancer patients. Oncoprint plot showing three classes of high confidence breast cancer-predisposing genes (rows); each column represents one of the samples with at least one of these mutations. Variants on known breast cancer-predisposing genes are indicated in blue (complete list in Table 1). A star indicates a variant that is a truncation but is not reported as pathogenic in the ClinVar or Humsavar databases. Pathogenic variants which affect genes related to cancer or cancer syndromes that are not linked to breast cancer are indicated in black and include genes like RET (thyroid cancer) or APC (colon cancer)

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