An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation

Table 5 Comparison of discrimination (AUCs) of PREDICT v1 and PREDICT v2, by data set and oestrogen receptor status

Study	ER status	Predict v1	Predict v2	P value
ECRIC	Negative	0.724	0.726	0.67
ECRIC	Positive	0.791	0.796	0.028
ECRIC	All	0.801	0.805	0.014
BCOS	Negative	0.650	0.632	0.87
BCOS	Positive	0.737	0.741	0.52
BCOS	All	0.737	0.734	0.45
NTBCS	Negative	0.671	0.680	0.32
NTBCS	Positive	0.787	0.790	0.57
NTBCS	All	0.770	0.772	0.63
POSH	Negative	0.717	0.715	0.76
POSH	Positive	0.741	0.746	0.36
POSH	All	0.735	0.741	0.22
Combined validation	Negative	0.698	0.696	0.70
Combined validation	Positive	0.750	0.760	0.016
Combined validation	All	0.747	0.752	0.058

Abbreviations: BCOS Breast Cancer Outcome Study of Mutation Carriers, ECRIC Eastern Cancer Registration and Information Centre, NTBCS Nottingham/Tenovus Breast Cancer Study, POSH Prospective study of Outcomes in Sporadic and Hereditary breast cancer

ISSN: 1465-542X