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Table 5 Comparison of discrimination (AUCs) of PREDICT v1 and PREDICT v2, by data set and oestrogen receptor status

From: An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation

Study ER status Predict v1 Predict v2 P value
ECRIC Negative 0.724 0.726 0.67
ECRIC Positive 0.791 0.796 0.028
ECRIC All 0.801 0.805 0.014
BCOS Negative 0.650 0.632 0.87
BCOS Positive 0.737 0.741 0.52
BCOS All 0.737 0.734 0.45
NTBCS Negative 0.671 0.680 0.32
NTBCS Positive 0.787 0.790 0.57
NTBCS All 0.770 0.772 0.63
POSH Negative 0.717 0.715 0.76
POSH Positive 0.741 0.746 0.36
POSH All 0.735 0.741 0.22
Combined validation Negative 0.698 0.696 0.70
Combined validation Positive 0.750 0.760 0.016
Combined validation All 0.747 0.752 0.058
  1. Abbreviations: BCOS Breast Cancer Outcome Study of Mutation Carriers, ECRIC Eastern Cancer Registration and Information Centre, NTBCS Nottingham/Tenovus Breast Cancer Study, POSH Prospective study of Outcomes in Sporadic and Hereditary breast cancer