|
Study
|
Number
|
Observed
|
Predicted
|
Difference (%)
|
P value
|
|---|
|
Total mortality
|
|
ECRIC
|
5738
|
1550
|
1600
|
3
|
0.21
|
|
BCOS
|
981
|
255
|
270
|
6
|
0.34
|
|
NTBCS
|
1944
|
488
|
468
|
−4
|
0.36
|
|
POSH
|
2609
|
544
|
621
|
12
|
0.00
|
|
Total
|
11,272
|
2837
|
2958
|
4
|
0.023
|
|
Breast cancer-specific mortality
|
|
ECRIC
|
5738
|
932
|
953
|
2
|
0.48
|
|
BCOS
|
981
|
227
|
244
|
7
|
0.25
|
|
NTBCS
|
1944
|
325
|
331
|
2
|
0.74
|
|
POSH
|
2609
|
527
|
581
|
9
|
0.018
|
|
Total
|
11,272
|
2011
|
2110
|
5
|
0.027
|
|
Non-breast cancer mortality
|
|
ECRIC
|
5738
|
618
|
646
|
4
|
0.25
|
|
BCOS
|
981
|
28
|
26
|
−9
|
0.66
|
|
NTBCS
|
1944
|
163
|
137
|
−19
|
0.039
|
|
POSH
|
2609
|
17
|
39
|
57
|
<0.001
|
|
Total
|
11,272
|
826
|
848
|
3
|
0.44
|
-
Abbreviations: BCOS Breast Cancer Outcome Study of Mutation Carriers, ECRIC Eastern Cancer Registration and Information Centre, NTBCS Nottingham/Tenovus Breast Cancer Study, POSH Prospective study of Outcomes in Sporadic and Hereditary breast cancer
