An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation

Table 2 Observed and predicted (PREDICT v2) deaths, by cause of death and data set

Study	Number	Observed	Predicted	Difference (%)	P value
Total mortality
ECRIC	5738	1550	1600	3	0.21
BCOS	981	255	270	6	0.34
NTBCS	1944	488	468	−4	0.36
POSH	2609	544	621	12	0.00
Total	11,272	2837	2958	4	0.023
Breast cancer-specific mortality
ECRIC	5738	932	953	2	0.48
BCOS	981	227	244	7	0.25
NTBCS	1944	325	331	2	0.74
POSH	2609	527	581	9	0.018
Total	11,272	2011	2110	5	0.027
Non-breast cancer mortality
ECRIC	5738	618	646	4	0.25
BCOS	981	28	26	−9	0.66
NTBCS	1944	163	137	−19	0.039
POSH	2609	17	39	57	<0.001
Total	11,272	826	848	3	0.44

Abbreviations: BCOS Breast Cancer Outcome Study of Mutation Carriers, ECRIC Eastern Cancer Registration and Information Centre, NTBCS Nottingham/Tenovus Breast Cancer Study, POSH Prospective study of Outcomes in Sporadic and Hereditary breast cancer

ISSN: 1465-542X