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Table 2 Observed and predicted (PREDICT v2) deaths, by cause of death and data set

From: An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation

Study

Number

Observed

Predicted

Difference (%)

P value

Total mortality

 ECRIC

5738

1550

1600

3

0.21

 BCOS

981

255

270

6

0.34

 NTBCS

1944

488

468

−4

0.36

 POSH

2609

544

621

12

0.00

 Total

11,272

2837

2958

4

0.023

Breast cancer-specific mortality

 ECRIC

5738

932

953

2

0.48

 BCOS

981

227

244

7

0.25

 NTBCS

1944

325

331

2

0.74

 POSH

2609

527

581

9

0.018

 Total

11,272

2011

2110

5

0.027

Non-breast cancer mortality

 ECRIC

5738

618

646

4

0.25

 BCOS

981

28

26

−9

0.66

 NTBCS

1944

163

137

−19

0.039

 POSH

2609

17

39

57

<0.001

 Total

11,272

826

848

3

0.44

  1. Abbreviations: BCOS Breast Cancer Outcome Study of Mutation Carriers, ECRIC Eastern Cancer Registration and Information Centre, NTBCS Nottingham/Tenovus Breast Cancer Study, POSH Prospective study of Outcomes in Sporadic and Hereditary breast cancer