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Fig. 2 | Breast Cancer Research

Fig. 2

From: Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models

Fig. 2

ESR1 mutant cells exhibit ligand-independent growth. T47D (a) and MCF7 (b) wild-type (WT) or mutant clones were hormone-deprived for 3 days, pooled, treated with vehicle or 1 nM estradiol (E2) for up to 8 days, and cell numbers were quantified by the FluoResporter kit. Growth fold change (FC) was normalized to day 0: **p < 0.01, one-way analysis of variance, comparison of FC growth between WT and mutant cells on the last day. The experiment was repeated three times with six biological replicates, and similar results were obtained

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