Age <50 years | Age ≥50 years | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Luminal A (n = 124) | TN/CBP (n = 128) | TN/CBP vs. luminal A | CBP (n = 65) | CBP vs. Luminal A | Luminal A (n = 130) | TN/CBP (n = 122) | TN/CBP vs. luminal A | CBP (n = 60) | CBP vs. luminal A | |||||||||||
Number | % | Number | % | OR (95% CI)a | P valuea | Number | % | OR (95% CI)a | P valuea | Number | % | Number | % | OR (95% CI)a | P valuea | Number | % | OR (95% CI)a | P valuea | |
TDLU count/100 mm2 | ||||||||||||||||||||
Median (IQR) | 29.7 | (17.4–40.2) | 30.4 | (16.9–48.4) | 30.8 | (19.0–46.8) | 11.7 | (5.66–18.1) | 11.62 | (5.81–21.7) | 10.1 | (4.2–20.4) | ||||||||
Tertile 1 | 39 | 31.5 | 45 | 35.2 | Reference | 20 | 30.8 | Reference | 43 | 33.1 | 41 | 33.6 | Reference | 26 | 43.3 | Reference | ||||
Tertile 2 | 50 | 40.3 | 34 | 26.6 | 0.57 (0.25–1.28) | 0.03 | 22 | 33.9 | 0.94 (0.34–2.58) | 0.28 | 47 | 36.2 | 37 | 30.3 | 0.59 (0.26–1.35) | 0.11 | 14 | 23.3 | 0.31 (0.11–0.84) | 0.02 |
Tertile 3 | 35 | 28.2 | 49 | 38.3 | 1.58 (0.70–3.57) | 0.04 | 23 | 35.4 | 2.29 (0.78–6.66) | 0.06 | 40 | 30.8 | 44 | 36.1 | 1.11 (0.48–2.59) | 0.32 | 20 | 33.3 | 0.77 (0.31–1.94) | 0.44 |
ORtrend/P trend | 1.27 (0.85– 1.91) | 0.25 | 1.52 (0.89– 2.61) | 0.13 | 1.05 (0.69– 1.60) | 0.81 | 0.86 (0.54– 1.38) | 0.54 | ||||||||||||
Maximum TDLU span (μm) | ||||||||||||||||||||
Median (IQR) | 904.0 | (705.5–1195.5) | 944.0 | (750–1161.5) | 985.0 | (796–1220) | 664.0 | (503–819) | 638 | (477–826) | 645.0 | (483.5–820) | ||||||||
Tertile 1 | 48 | 38.7 | 36 | 28.1 | Reference | 17 | 26.2 | Reference | 44 | 33.9 | 40 | 32.8 | Reference | 19 | 31.7 | Reference | ||||
Tertile 2 | 35 | 28.2 | 49 | 38.3 | 2.12 (0.96–4.66) | 0.13 | 23 | 35.4 | 2.03 (0.74–5.54) | 0.43 | 42 | 32.3 | 42 | 34.4 | 0.75 (0.32–1.75) | 0.39 | 22 | 36.7 | 0.87 (0.33–2.31) | 0.77 |
Tertile 3 | 41 | 33.1 | 43 | 33.6 | 1.55 (0.70–3.45) | 0.85 | 25 | 38.5 | 2.06 (0.75–5.67) | 0.40 | 44 | 33.9 | 40 | 32.8 | 1.04 (0.44–2.43) | 0.62 | 19 | 31.7 | 0.96 (0.36–2.54) | 0.94 |
ORtrend/P trend | 1.25 (0.84– 1.85) | 0.28 | 1.43 (0.87– 2.36) | 0.16 | 1.03 (0.67– 1.58) | 0.89 | 0.99 (0.61– 1.60) | 0.95 | ||||||||||||
Maximum category of acini count/TDLUb | ||||||||||||||||||||
Median (IQR) | 4.0 | (3–5) | 4.0 | (3–5) | 4.0 | (3–5) | 2.0 | (2.3) | 2 | (2–4) | 2.0 | (1–3) | ||||||||
Tertile 1 | 46 | 37.1 | 39 | 30.5 | Reference | 17 | 26.2 | Reference | 76 | 58.5 | 63 | 51.6 | Reference | 32 | 53.3 | Reference | ||||
Tertile 2 | 34 | 27.4 | 38 | 29.7 | 1.61 (0.71–3.68) | 0.62 | 17 | 26.2 | 1.63 (0.55–4.86) | 0.59 | 54 | 41.5 | 59 | 48.4 | 1.40 (0.71– 2.75)b | 0.33b | 28 | 46.7 | 1.25 (0.58– 2.69)b | 0.57b |
Tertile 3 | 44 | 35.5 | 51 | 39.8 | 1.82 (0.82–4.00) | 0.30 | 31 | 47.7 | 4.39 (1.45–13.23) | 0.009 | ||||||||||
ORtrend/P trend | 1.34 (0.90– 1.99) | 0.14 | 2.11 (1.22– 3.67) | 0.008 |