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Table 3 Association of terminal duct lobular unit involution with breast tumor subtypes, by age group

From: Age-related terminal duct lobular unit involution in benign tissues from Chinese breast cancer patients with luminal and triple-negative tumors

 

Age <50 years

Age ≥50 years

Luminal A (n = 124)

TN/CBP (n = 128)

TN/CBP vs. luminal A

CBP (n = 65)

CBP vs. Luminal A

Luminal A (n = 130)

TN/CBP (n = 122)

TN/CBP vs. luminal A

CBP (n = 60)

CBP vs. luminal A

Number

%

Number

%

OR (95% CI)a

P valuea

Number

%

OR (95% CI)a

P valuea

Number

%

Number

%

OR (95% CI)a

P valuea

Number

%

OR (95% CI)a

P valuea

TDLU count/100 mm2

 Median (IQR)

29.7

(17.4–40.2)

30.4

(16.9–48.4)

  

30.8

(19.0–46.8)

  

11.7

(5.66–18.1)

11.62

(5.81–21.7)

  

10.1

(4.2–20.4)

  

 Tertile 1

39

31.5

45

35.2

Reference

 

20

30.8

Reference

 

43

33.1

41

33.6

Reference

 

26

43.3

Reference

 

 Tertile 2

50

40.3

34

26.6

0.57 (0.25–1.28)

0.03

22

33.9

0.94 (0.34–2.58)

0.28

47

36.2

37

30.3

0.59 (0.26–1.35)

0.11

14

23.3

0.31 (0.11–0.84)

0.02

 Tertile 3

35

28.2

49

38.3

1.58 (0.70–3.57)

0.04

23

35.4

2.29 (0.78–6.66)

0.06

40

30.8

44

36.1

1.11 (0.48–2.59)

0.32

20

33.3

0.77 (0.31–1.94)

0.44

 ORtrend/P trend

    

1.27 (0.85– 1.91)

0.25

  

1.52 (0.89– 2.61)

0.13

    

1.05 (0.69– 1.60)

0.81

  

0.86 (0.54– 1.38)

0.54

Maximum TDLU span (μm)

 Median (IQR)

904.0

(705.5–1195.5)

944.0

(750–1161.5)

  

985.0

(796–1220)

  

664.0

(503–819)

638

(477–826)

  

645.0

(483.5–820)

  

 Tertile 1

48

38.7

36

28.1

Reference

 

17

26.2

Reference

 

44

33.9

40

32.8

Reference

 

19

31.7

Reference

 

 Tertile 2

35

28.2

49

38.3

2.12 (0.96–4.66)

0.13

23

35.4

2.03 (0.74–5.54)

0.43

42

32.3

42

34.4

0.75 (0.32–1.75)

0.39

22

36.7

0.87 (0.33–2.31)

0.77

 Tertile 3

41

33.1

43

33.6

1.55 (0.70–3.45)

0.85

25

38.5

2.06 (0.75–5.67)

0.40

44

33.9

40

32.8

1.04 (0.44–2.43)

0.62

19

31.7

0.96 (0.36–2.54)

0.94

 ORtrend/P trend

    

1.25 (0.84– 1.85)

0.28

  

1.43 (0.87– 2.36)

0.16

    

1.03 (0.67– 1.58)

0.89

  

0.99 (0.61– 1.60)

0.95

Maximum category of acini count/TDLUb

 Median (IQR)

4.0

(3–5)

4.0

(3–5)

  

4.0

(3–5)

  

2.0

(2.3)

2

(2–4)

  

2.0

(1–3)

  

 Tertile 1

46

37.1

39

30.5

Reference

 

17

26.2

Reference

 

76

58.5

63

51.6

Reference

 

32

53.3

Reference

 

 Tertile 2

34

27.4

38

29.7

1.61 (0.71–3.68)

0.62

17

26.2

1.63 (0.55–4.86)

0.59

54

41.5

59

48.4

1.40 (0.71– 2.75)b

0.33b

28

46.7

1.25 (0.58– 2.69)b

0.57b

 Tertile 3

44

35.5

51

39.8

1.82 (0.82–4.00)

0.30

31

47.7

4.39 (1.45–13.23)

0.009

          

 ORtrend/P trend

    

1.34 (0.90– 1.99)

0.14

  

2.11 (1.22– 3.67)

0.008

          
  1. Abbreviations: CBP Core basal phenotype, TDLU Terminal duct lobular unit, TN Triple-negative
  2. aORs, 95% CIs, and P values were obtained from logistic regression analyses comparing cases with TN/CBP tumors or CBP tumors only with cases with luminal A tumors, adjusted for age (5–year intervals), body mass index (<23, 23–24.9, 25–29.9, or 30+ kg/m2), parity (nulliparous, one child, or more than one child), and tumor grade (well, moderately, or poorly differentiated)
  3. bNumber of acini was analyzed as the binary variable (greater than or equal to the median vs. below the median). Tertile categorization was not used, owing to the uneven distribution in acini count/TDLU among older women