Table 2 Association of terminal duct lobular unit involution with breast tumor subtypes among overall cases
Overall (n = 504) | Luminal A (n = 254) | TN/CBP (n = 250) | TN/CBP vs. luminal A | CBP (n = 125) | CBP vs. luminal A | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI)a | P valuea | OR (95% CI)a | P valuea | |||||||||
TDLU count/100 mm2 | ||||||||||||
Median (IQR) | 18.3 | (9–35) | 37 | (18.0–65.0) | 42 | (20.0–75.0) | 46 | (20–75) | ||||
Tertile 1 | 168 | 33.3 | 87 | 34.3 | 81 | 32.4 | Reference | 41 | 32.8 | Reference | ||
Tertile 2 | 168 | 33.3 | 87 | 34.3 | 81 | 32.4 | 0.83 (0.47–1.49) | 0.14 | 40 | 32.0 | 0.83 (0.41–1.67) | 0.18 |
Tertile 3 | 168 | 33.3 | 80 | 31.5 | 88 | 35.0 | 1.44 (0.77–2.70) | 0.09 | 44 | 35.2 | 1.23 (0.71–3.28) | 0.11 |
ORtrend/P trend | 1.18 (0.86– 1.62) | 0.31 | 1.24 (0.84– 1.82) | 0.28 | ||||||||
Maximum TDLU span (μm) | ||||||||||||
Median (IQR) | 775 | (589.5–1023.0) | 764.5 | (600.0–992.0) | 803 | (588.0–1043.0) | 809 | (624.0–1100.0) | ||||
Tertile 1 | 168 | 33.3 | 83 | 32.7 | 85 | 34.0 | Reference | 39 | 31.2 | Reference | ||
Tertile 2 | 169 | 33.5 | 91 | 35.8 | 78 | 31.2 | 0.69 (0.39–1.22) | 0.05 | 38 | 30.4 | 0.78 (0.39–1.57) | 0.12 |
Tertile 3 | 167 | 33.1 | 80 | 31.5 | 87 | 34.8 | 1.25 (0.67–2.30) | 0.13 | 48 | 38.4 | 1.53 (0.73–3.18) | 0.08 |
ORtrend/P trend | 1.12 (0.82– 1.52) | 0.48 | 1.26 (0.87– 1.82) | 0.22 | ||||||||
Maximum category of acini count/TDLU | ||||||||||||
Median (IQR) | 3 | (2.0–4.0) | 3 | (2.0–4.0) | 3 | (2.0–5.0) | 3 | (2.0–5.0) | ||||
Tertile 1 | 176 | 34.9 | 97 | 38.2 | 79 | 31.6 | Reference | 39 | 31.2 | Reference | ||
Tertile 2 | 211 | 41.9 | 103 | 40.6 | 108 | 43.2 | 1.57 (0.89–2.77) | 0.70 | 47 | 37.6 | 1.24 (0.62–2.47) | 0.27 |
Tertile 3 | 117 | 23.2 | 54 | 21.3 | 63 | 25.2 | 2.06 (1.03–4.11) | 0.09 | 39 | 31.2 | 2.89 (1.27–6.55) | 0.006 |
ORtrend/P trend | 1.42 (1.01– 2.01) | 0.045 | 1.69 (1.12– 2.55) | 0.012 | ||||||||