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Table 5 The associations of weight and height with breast development among girls aged 5–7 years old at first visit using Weibull longitudinal models; LEGACY Girls Study

From: Pubertal development in girls by breast cancer family history: the LEGACY girls cohort

 

Hazard ratio (95% confidence interval)

Overall

BCFH+ girls

BCFH– girls

Breast Tanner stage T2+

 n

248

127

121

 Model 1a

 Weight (per 1 kg)

1.05 (1.03–1.08)

1.05 (1.02–1.08)

1.10 (1.03–1.17)

 Height (per 1 cm)

1.01 (0.98–1.04)

0.99 (0.95–1.02)

0.98 (0.93–1.04)

 Race/ethnicity

  Non-Hispanic white

1 (reference)

1 (reference)

1 (reference)

  Asian

1.12 (0.54–2.35)

1.18 (0.35–3.98)

1.31 (0.53–3.25)

  Black

1.31 (0.73–2.37)

1.36 (0.76–2.42)

1.51 (0.56–4.08)

  Hispanic

1.52 (0.95–2.44)

2.75 (1.48–5.11)

0.88 (0.37–2.08)

 Model 2b

 Overweight (≥85th percentile)

3.61 (2.16–6.02)

2.02 (0.99–4.11)

9.40 (4.94–17.91)

  1. BCFH breast cancer family history
  2. aModel is adjusted for age as the underlying time scale and includes weight, height, and race/ethnicity. Mixed race/ethnicity is excluded due to small cell counts
  3. bModel is adjusted for age as the underlying time scale and includes overweight, height, and race/ethnicity. Mixed race/ethnicity is excluded due to small cell counts