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Table 5 The associations of weight and height with breast development among girls aged 5–7 years old at first visit using Weibull longitudinal models; LEGACY Girls Study

From: Pubertal development in girls by breast cancer family history: the LEGACY girls cohort

  Hazard ratio (95% confidence interval)
Overall BCFH+ girls BCFH– girls
Breast Tanner stage T2+
 n 248 127 121
 Model 1a
 Weight (per 1 kg) 1.05 (1.03–1.08) 1.05 (1.02–1.08) 1.10 (1.03–1.17)
 Height (per 1 cm) 1.01 (0.98–1.04) 0.99 (0.95–1.02) 0.98 (0.93–1.04)
 Race/ethnicity
  Non-Hispanic white 1 (reference) 1 (reference) 1 (reference)
  Asian 1.12 (0.54–2.35) 1.18 (0.35–3.98) 1.31 (0.53–3.25)
  Black 1.31 (0.73–2.37) 1.36 (0.76–2.42) 1.51 (0.56–4.08)
  Hispanic 1.52 (0.95–2.44) 2.75 (1.48–5.11) 0.88 (0.37–2.08)
 Model 2b
 Overweight (≥85th percentile) 3.61 (2.16–6.02) 2.02 (0.99–4.11) 9.40 (4.94–17.91)
  1. BCFH breast cancer family history
  2. aModel is adjusted for age as the underlying time scale and includes weight, height, and race/ethnicity. Mixed race/ethnicity is excluded due to small cell counts
  3. bModel is adjusted for age as the underlying time scale and includes overweight, height, and race/ethnicity. Mixed race/ethnicity is excluded due to small cell counts