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Table 3 Associations of measures of breast cancer family history (BCFH) with breast development among girls aged 5–7 years at first visit using Weibull longitudinal models; LEGACY Girls Study

From: Pubertal development in girls by breast cancer family history: the LEGACY girls cohort

  Hazard ratio (95% confidence interval)
  All girls aged 5–7 years at first visit Girls aged 5–7 years at first visit, BMI <85th percentile
Measures of BCFHa Model 1b Model 2c, d Model 1b Model 2c, d
  n = 258 n = 248 n = 210 n = 206
Any BCFH 1.33 (0.93–1.91) 1.49 (1.00–2.21) 1.69 (1.12–2.55) 2.04 (1.29–3.21)
First-degree BCFH 1.28 (0.83–1.98) 1.24 (0.76–2.03) 1.88 (1.13–3.12) 2.21 (1.31–3.73)
Second-degree BCFH only 1.38 (0.93–2.04) 1.68 (1.09–2.59) 1.63 (1.03–2.56) 1.94 (1.17–3.24)
  1. aNo BCFH is the referent group for all models
  2. bAdjusted for age as the underlying time scale
  3. cAdjusted for age as the underlying time scale, body mass index at baseline, and race/ethnicity
  4. dGirls with mixed race/ethnicity were excluded due to small cell counts