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Table 2 Associations of measures of breast cancer family history (BCFH) with pubertal outcomes; LEGACY Girls Study

From: Pubertal development in girls by breast cancer family history: the LEGACY girls cohort

  Odds ratio (95% confidence interval)
  Breast Tanner stage T2 + a Pubic hair Tanner stage T2 + a Post-menarche statusb
Measures of BCFHc Model 1d Model 2e Model 1d Model 2e Model 1d Model 2f
  n = 801 n = 786 n = 835 n = 819 n = 506 n = 493
Any BCFH 1.35
(0.92–1.98)
1.36
(0.88–2.10)
0.83
(0.58–1.20)
0.81
(0.55–1.20)
0.69
(0.42–1.14)
0.69
(0.38–1.23)
First-degree BCFH 1.05
(0.63–1.75)
0.99
(0.58–1.68)
0.98
(0.60–1.58)
0.94
(0.58–1.55)
0.66
(0.35–1.25)
0.67
(0.32–1.38)
Second-degree BCFH Only 1.60
(1.03–2.50)
1.80
(1.07–3.05)
0.76
(0.50–1.16)
0.75
(0.48–1.17)
0.74
(0.41–1.32)
0.72
(0.35–1.47)
  1. aModels exclude girls aged ≥13 years (n = 135)
  2. bExcludes girls aged <10 years (n = 510)
  3. cNo BCFH is the referent group for all models
  4. dAdjusted for age
  5. eAdjusted for age, body mass index (BMI), race/ethnicity, and study site
  6. fAdjusted for age, BMI, race/ethnicity, site, and BMI × age