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Table 2 Associations of measures of breast cancer family history (BCFH) with pubertal outcomes; LEGACY Girls Study

From: Pubertal development in girls by breast cancer family history: the LEGACY girls cohort

 

Odds ratio (95% confidence interval)

 

Breast Tanner stage T2 + a

Pubic hair Tanner stage T2 + a

Post-menarche statusb

Measures of BCFHc

Model 1d

Model 2e

Model 1d

Model 2e

Model 1d

Model 2f

 

n = 801

n = 786

n = 835

n = 819

n = 506

n = 493

Any BCFH

1.35

(0.92–1.98)

1.36

(0.88–2.10)

0.83

(0.58–1.20)

0.81

(0.55–1.20)

0.69

(0.42–1.14)

0.69

(0.38–1.23)

First-degree BCFH

1.05

(0.63–1.75)

0.99

(0.58–1.68)

0.98

(0.60–1.58)

0.94

(0.58–1.55)

0.66

(0.35–1.25)

0.67

(0.32–1.38)

Second-degree BCFH Only

1.60

(1.03–2.50)

1.80

(1.07–3.05)

0.76

(0.50–1.16)

0.75

(0.48–1.17)

0.74

(0.41–1.32)

0.72

(0.35–1.47)

  1. aModels exclude girls aged ≥13 years (n = 135)
  2. bExcludes girls aged <10 years (n = 510)
  3. cNo BCFH is the referent group for all models
  4. dAdjusted for age
  5. eAdjusted for age, body mass index (BMI), race/ethnicity, and study site
  6. fAdjusted for age, BMI, race/ethnicity, site, and BMI × age