Fig. 2

Box plots depicting inter- and intrasite reproducibility. The box plots represent the distribution of the four MammaTyper® measurements of the eight centrally extracted RNA samples for each marker at the ten different study sites A–J (study arm 1). The box plots indicate the median 40^−∆∆Cq values by the horizontal line dividing the boxes, the first and third quartiles by the lower and upper borders of the boxes, and the minimum and maximum values by the whiskers. The graphs at the bottom show the interrun SD over all samples for each marker at the respective site, as well as the corresponding 95% CI. ERBB2 (HER2) Human epidermal growth factor receptor 2, ESR1 (ER) Estrogen receptor, MKI67 Marker of proliferation Ki67, PGR (PgR) Progesterone receptor