Fig. 1
From: TIMELESS contributes to the progression of breast cancer through activation of MYC
High expression of TIM predicts poor prognosis in patients with breast cancer. a TIM expression in normal breast epithelial cells (NBECs) and breast cancer cells determined by western blot. b TIM expression in four paired primary breast cancer tissue samples (T) and matched normal breast tissue samples (N) determined by western blot. β-actin was used as a loading control. c Immunohistochemistry (IHC) staining of TIM expression in breast cancer tissue came from patients with poor prognosis (less than 5-year survival) and good prognosis (more than 5-year survival). Representative photographs of IHC analysis of breast cancer tissue (left panel) and association between TIM expression and prognosis (right panel). ***P < 0.001. d Kaplan-Meier survival curves indicating the overall survival and relapse-free survival in patients with breast cancer who had high or low protein levels of TIM. e Multivariate analysis of clinical factors using a Cox regression model. T stage tumor stage, N stage nodal stage, M stage metastatic stage