From: A phase-I study of lapatinib in combination with foretinib, a c-MET, AXL and vascular endothelial growth factor receptor inhibitor, in human epidermal growth factor receptor 2 (HER-2)-positive metastatic breast cancer
Dose level
Foretinib/lapatinib dose
Number of cycles
Number of patients
1
30 mg/750 mg
2
20
30 mg/1000 mg
5
3
45 mg/1000 mg
3–4
4
45 mg/1250 mg
1–2
6