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Table 3 CSF flow cytometry characterization of the infiltrating leukocyte in 13 cases of breast cancer leptomeningeal metastasis

From: Overexpression of syndecan-1, MUC-1, and putative stem cell markers in breast cancer leptomeningeal metastasis: a cerebrospinal fluid flow cytometry study

Case number

CD45-positive cells (%)

Leucocytes distribution among the CD45+ population

CSF lymphocytes subpopulation

% lymphocytes (CD45 SSC)

% monocytes (CD14+)

% neutrophils (CD15+)

% CD3

% CD56

% CD3/CD4

% CD3/CD8

% CD3/CD56

T4/T8 ratio

% CD19

1

91

16

6

78

93

9

67

32

4

2.09

1

2

53

42

38

20

94

8

58

42

9

1.38

1

3

57

85

12

3

92

9

63

30

4

2.1

0

4

4

70

18

12

94

5

58

41

1

1.41

0

5

96

84

10

6

97

6

63

36

5

1.75

1

6

80

80

19

1

96

3

68

30

1

2.26

1

7

80

64

29

7

92

10

58

40

4

1.45

0

8

65

74

22

4

98

24

68

33

30

2.06

0

9

53

55

40

5

85

10

47

51

5

0.9

0

10

60

40

57

3

87

19

47

53

7

0.9

3

11

40

85

12

3

92

6

45

52

3

0.86

0

12

55

80

12

8

83

14

58

43

4

1.34

3

13

64

6

12

82

75

5

59

36

2

1.6

0

  1. The CSF lymphocytes immunophenotype is reported as percentage of positive cells within the lymphoid population, identified as CD45-strong/intermediate side-scatter signals
  2. CSF cerebrospinal fluid, BC breast cancer