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Fig. 6 | Breast Cancer Research

Fig. 6

From: Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer

Fig. 6

Potential pathway through which stress hormones may stimulate the production of reactive nitrogen species (RNS)/reactive oxygen species (ROS). Glucocorticoid (GC) and norepinephrine (NE) induce DNA damage through the production of RNS/ROS. Activation of the glucocorticoid receptor (GR) may facilitate non-genomic effects on inducible nitric oxide synthase (iNOS) through a post-translational modification. Binding of glucocorticoids to the GR promotes translocation to the nucleus to act on GR response elements (GRE), facilitating transactivation or transrepression of genes. Binding also induces conformational changes including dissociation of a multiprotein complex comprising heat shock proteins (HSP) and Src. Src may then mediate phosphorylation of iNOS extending its half-life and promoting the generation of nitric oxide (NO). H 2 O 2 hydrogen peroxide, β-AR β-Adrenergic receptor

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Breast Cancer Research

ISSN: 1465-542X

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