Category of EZH2 expression in normal TDLU epithelium | |||
---|---|---|---|
0–10% (n = 184) | 11–20% (n = 55) | >20% (n = 30) | |
Age at cancer diagnosis/index datea | 52.92 (8.20) | 50.35 (7.20) | 47.77 (8.11) |
Year of BBD biopsy | |||
Before 1980, % | 42 | 33 | 46 |
1980–1989, % | 44 | 53 | 43 |
After 1989, % | 14 | 14 | 11 |
Time from biopsy to diagnosis/index date | |||
0.5–4.9 years, % | 48 | 50 | 45 |
5.0–9.9 years, % | 25 | 23 | 18 |
10.0–14.9 years, % | 19 | 20 | 34 |
15.0+ years, % | 9 | 7 | 4 |
BBD category | |||
Non-proliferative, % | 32 | 28 | 29 |
Proliferative without atypia, % | 53 | 61 | 66 |
Atypical hyperplasia, % | 15 | 12 | 5 |
Age at first birth | |||
Nulliparous, % | 6 | 2 | 0 |
<25 years, % | 57 | 42 | 71 |
25–29 years, % | 30 | 42 | 13 |
30+ years, % | 6 | 11 | 5 |
Missing, % | 2 | 3 | 11 |
Duration of breastfeeding (months)b | |||
0 months, % | 37 | 37 | 22 |
0–3 months, % | 20 | 19 | 50 |
4–11 months, % | 20 | 26 | 7 |
12+ months, % | 21 | 15 | 18 |
Missing, % | 2 | 4 | 2 |
Age at menarche (years) | |||
< 12, % | 24 | 19 | 20 |
12, % | 26 | 19 | 32 |
13, % | 26 | 41 | 32 |
14+, % | 23 | 21 | 16 |
Menopausal status/age at menopause (years) | |||
Premenopausal, % | 42 | 43 | 48 |
< 50, % | 29 | 30 | 36 |
50+, % | 24 | 19 | 16 |
Missing, % | 5 | 9 | 0 |
Postmenopausal hormone therapy use | |||
Never, % | 26 | 24 | 33 |
Ever, % | 30 | 25 | 16 |
Premenopausal, % | 43 | 49 | 51 |
Missing, % | 1 | 2 | 0 |
Oral contraceptive use | |||
Never, % | 51 | 50 | 34 |
Ever, % | 46 | 50 | 66 |
Missing, % | 3 | 0 | 0 |
BMI (kg/m2) | |||
< 25.0, % | 61 | 68 | 71 |
25.0–29.9, % | 26 | 14 | 26 |
30.0+, % | 13 | 17 | 4 |
Weight change since age 18 years | |||
Gain <2 kg, % | 17 | 13 | 16 |
Gain 2–10 kg, % | 34 | 39 | 46 |
Gain 10+ kg, % | 39 | 44 | 32 |
Missing, % | 10 | 3 | 5 |
Alcohol consumption (g/week) | |||
None, % | 37 | 36 | 36 |
0.1–4.9, % | 32 | 32 | 42 |
5.0–14.9, % | 23 | 15 | 11 |
15.0+, % | 9 | 17 | 11 |
Family history of breast cancer | |||
No family history, % | 81 | 91 | 82 |
Family history, % | 19 | 9 | 18 |