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Table 2 Associations between patient immune profile and biomarkers of ageing in the whole population (the CTG and CG) prior to receiving any systemic therapy

From: Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty

Feature Phenotype p Value r Value Number
Telomere length CD8 + effector memory 0.003 r = –0.482 n = 36
Telomere length CD4 + Helios+ 0.031 r = 0.361 n = 36
IL-6 CD4 + CD57+ 0.025 r = –0.316 n = 50
IL-6 CD3 + CD4+ 0.034 r = 0.298 n = 51
IL-6 CD8 + Helios+ 0.014 r = 0.343 n = 51
IL-6 Lin-CD14-HLA-DR- 0.014 r = –0.332 n = 54
IL-10 CD8+/TEMRA 0.030 r = 0.307 n = 50
IGF-1 CD4 + CD57+ 0.035 r = 0.299 n = 50
IGF-1 CD4 + CD25hi FOXP3+ 0.044 r = 0.283 n = 51
TNF CD4 + CD25hi FOXP3+ 0.019 r = –0.326 n = 51
TNF CD4 + FOXP3+ 0.045 r = –0.282 n = 51
TNF CD8 + Helios+ 0.025 r = 0.315 n = 51
TNF CD14 + CD124+ 0.003 r = 0.392 n = 54
TNF CD15+ 0.020 r = −0.317 n = 54
TNF Lin- 0.009 r = 0.353 n = 54
TNF Lin-CD14- 0.029 r = 0.297 n = 54
MCP-1 Lin-CD14+ 0.018 r = 0.320 n = 54
RANTES CD4+ 0.017 r = –0.337 n = 50
RANTES CD8+/TEMRA 0.012 r = −0.352 n = 50
RANTES CD3 + CD4+ 0.012 r = −0.350 n = 51
RANTES CD8 + FOXP3++ 0.001 r = 0.434 n = 51
RANTES CD14-CD15 + CD124+ 0.006 r = 0.370 n = 54
RANTES Lin-CD14-HLA-DR- 0.009 r = 0.354 n = 54
CMV CD4 + CD27+ 0.031↓   n = 47
CMV CD4 + CD27+ CD28+ 0.044↓   n = 47
CMV CD4+/Central memory 0.037↓   n = 47
CMV CD4 + CD27- CD28- <0.001↑   n = 47
CMV CD4+/TEMRA 0.013↑   n = 47
CMV CD4+/Effector memory <0.001↑   n = 47
CMV CD4 + CD28+ <0.001↑   n = 47
CMV CD8+ 0.020↑   n = 47
CMV CD8 + CD27 0.021↓   n = 47
CMV CD8 + CD27 + CD28+ 0.008↓   n = 47
CMV CD8+/Central memory 0.033↓   n = 47
CMV CD8 + CD27- CD28- <0.001↑   n = 47
CMV CD8+/TEMRA <0.001↑   n = 47
CMV CD8 + CD28+ 0.007↓   n = 47
CMV CD4CD8 ratio 0.004↓   n = 47
CMV CD8 + FOXP3++ 0.039↓   n = 48
  1. Negative r values indicate inverse association and positive r values indicate positive correlation between the patient feature (“Feature”) and the leukocyte population (“Phenotype”); ↓ indicates that cytomegalovirus (CMV) positive status is associated with lower values of the particular cell population and ↑ indicates higher values. CTG chemotherapy group, CG control group, IGF insulin-like growth factor, MCP monocyte chemattractant protein, RANTES regulated on activation, normal T cell expressed and secreted