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Table 2 Associations between patient immune profile and biomarkers of ageing in the whole population (the CTG and CG) prior to receiving any systemic therapy

From: Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty

Feature

Phenotype

p Value

r Value

Number

Telomere length

CD8 + effector memory

0.003

r = –0.482

n = 36

Telomere length

CD4 + Helios+

0.031

r = 0.361

n = 36

IL-6

CD4 + CD57+

0.025

r = –0.316

n = 50

IL-6

CD3 + CD4+

0.034

r = 0.298

n = 51

IL-6

CD8 + Helios+

0.014

r = 0.343

n = 51

IL-6

Lin-CD14-HLA-DR-

0.014

r = –0.332

n = 54

IL-10

CD8+/TEMRA

0.030

r = 0.307

n = 50

IGF-1

CD4 + CD57+

0.035

r = 0.299

n = 50

IGF-1

CD4 + CD25hi FOXP3+

0.044

r = 0.283

n = 51

TNF

CD4 + CD25hi FOXP3+

0.019

r = –0.326

n = 51

TNF

CD4 + FOXP3+

0.045

r = –0.282

n = 51

TNF

CD8 + Helios+

0.025

r = 0.315

n = 51

TNF

CD14 + CD124+

0.003

r = 0.392

n = 54

TNF

CD15+

0.020

r = −0.317

n = 54

TNF

Lin-

0.009

r = 0.353

n = 54

TNF

Lin-CD14-

0.029

r = 0.297

n = 54

MCP-1

Lin-CD14+

0.018

r = 0.320

n = 54

RANTES

CD4+

0.017

r = –0.337

n = 50

RANTES

CD8+/TEMRA

0.012

r = −0.352

n = 50

RANTES

CD3 + CD4+

0.012

r = −0.350

n = 51

RANTES

CD8 + FOXP3++

0.001

r = 0.434

n = 51

RANTES

CD14-CD15 + CD124+

0.006

r = 0.370

n = 54

RANTES

Lin-CD14-HLA-DR-

0.009

r = 0.354

n = 54

CMV

CD4 + CD27+

0.031↓

 

n = 47

CMV

CD4 + CD27+ CD28+

0.044↓

 

n = 47

CMV

CD4+/Central memory

0.037↓

 

n = 47

CMV

CD4 + CD27- CD28-

<0.001↑

 

n = 47

CMV

CD4+/TEMRA

0.013↑

 

n = 47

CMV

CD4+/Effector memory

<0.001↑

 

n = 47

CMV

CD4 + CD28+

<0.001↑

 

n = 47

CMV

CD8+

0.020↑

 

n = 47

CMV

CD8 + CD27

0.021↓

 

n = 47

CMV

CD8 + CD27 + CD28+

0.008↓

 

n = 47

CMV

CD8+/Central memory

0.033↓

 

n = 47

CMV

CD8 + CD27- CD28-

<0.001↑

 

n = 47

CMV

CD8+/TEMRA

<0.001↑

 

n = 47

CMV

CD8 + CD28+

0.007↓

 

n = 47

CMV

CD4CD8 ratio

0.004↓

 

n = 47

CMV

CD8 + FOXP3++

0.039↓

 

n = 48

  1. Negative r values indicate inverse association and positive r values indicate positive correlation between the patient feature (“Feature”) and the leukocyte population (“Phenotype”); ↓ indicates that cytomegalovirus (CMV) positive status is associated with lower values of the particular cell population and ↑ indicates higher values. CTG chemotherapy group, CG control group, IGF insulin-like growth factor, MCP monocyte chemattractant protein, RANTES regulated on activation, normal T cell expressed and secreted