| |
Inclusion vs 3 months (CTG)
|
Inclusion vs 1 year (CTG)
|
Time by group interaction
|
|---|
|
Mean difference (95% CI)
|
p Value
|
Mean difference (95% CI)
|
p Value
|
p Value
|
|---|
|
CD4 + CD27+
|
–1.64 (–7.27; 3.98)
|
0.561
|
8.34 (1.53; 15.15)
|
0.017
|
0.317
|
|
CD4 + CD28+
|
–2.11 (–6.33; 2.11)
|
0.321
|
5.78 (0.71; 10.85)
|
0.026
|
0.018
|
|
CD4 + CD27 + CD28+
|
–0.55 (–5.92; 4.81)
|
0.836
|
8.72 (2.22; 15.22)
|
0.009
|
0.328
|
|
CD4+/central memory
|
2.65 (–0.57; 5.88)
|
0.105
|
6.44 (3.4; 9.48)
|
<0.001
|
0.114
|
|
CD4 + CD27–
|
0.34 (0.11; 0.57)
|
0.005
|
–0.26 (–0.47; –0.04)
|
0.020
|
<0.001
|
|
CD4+/TEMRA
|
0.23 (0.03; 0.43)
|
0.028
|
–0.09 (–0.28; 0.1)
|
0.343
|
0.008
|
|
CD8+
|
7.69 (2.62; 12.75)
|
0.004
|
4.04 (–0.72; 8.8)
|
0.095
|
0.116
|
|
CD8 + CD27+
|
–4.77 (–8.8; –0.74)
|
0.021
|
2.10 (–1.85; 6.06)
|
0.292
|
0.008
|
|
CD8 + CD28+
|
–5.53 (–11.3; 0.24)
|
0.060
|
3.99 (–2.84; 10.83)
|
0.246
|
0.011
|
|
CD8 + CD27 + CD28+
|
–4.31 (–8.15; –0.46)
|
0.029
|
3.91 (0.62; 7.2)
|
0.021
|
0.004
|
|
CD8 + CD27-CD28–
|
6.35 (1.78; 10.92)
|
0.007
|
–4.42 (–9.18; 0.35)
|
0.068
|
<0.001
|
|
CD8+/central memory
|
–0.15 (–0.35; 0.05)
|
0.130
|
0.27 (0.07; 0.48)
|
0.009
|
0.01
|
|
CD8+/naive
|
–0.16 (–0.40; 0.09)
|
0.204
|
0.29 (0.06; 0.52)
|
0.014
|
0.151
|
|
CD4/CD8 ratio
|
–0.19 (–0.32; –0.07)
|
0.003
|
0.02 (–011; 0.15)
|
0.757
|
0.022
|
|
CD4 + CD25hi FOXP3+
|
–0.02 (–0.19; 0.15)
|
0.857
|
0.17 (0.02; 0.33)
|
0.028
|
0.185
|
|
CD4 + Helios+
|
–0.07 (–1.14; 1.01)
|
0.903
|
0.99 (0.18; 1.8)
|
0.017
|
0.511
|
|
Lin-CD14+
|
0.20 (–0.07; 0.47)
|
0.151
|
0.58 (0.33; 0.83)
|
<0.001
|
0.021
|
|
CD14 + HLA-DR–
|
0.13 (0.01; 0.26)
|
0.039
|
0.21 (0.08; 0.34)
|
0.002
|
0.591
|
|
CD14 + CD124+
|
0.06 (0.01; 0.11)
|
0.014
|
0.07 (0.02; 0.12)
|
0.009
|
0.092
|
|
CD15+
|
0.44 (0.04; 0.83)
|
0.031
|
–0.57 (–1.15; 0.01)
|
0.054
|
0.018
|
- Mean differences are shown in measurements made at inclusion and at 3 months (n = 28) and at inclusion and at 1 year (n = 28) in the chemotherapy group (CTG), and these were compared to patients who did not receive chemotherapy (Time by group interaction) (n = 28). Only cell populations with statistically significant relationships are shown. Naïve CD45RA + CCR7 + CD27 + CD28+, Central memory CD45RA-CCR7 + CD27 + CD28+, TEMRA CD45RA + CCR7-CD27-CD28–. P values in bold are statistically significant
