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Table 1 Changes in immune profile in patients undergoing chemotherapy

From: Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty

  Inclusion vs 3 months (CTG) Inclusion vs 1 year (CTG) Time by group interaction
Mean difference (95% CI) p Value Mean difference (95% CI) p Value p Value
CD4 + CD27+ –1.64 (–7.27; 3.98) 0.561 8.34 (1.53; 15.15) 0.017 0.317
CD4 + CD28+ –2.11 (–6.33; 2.11) 0.321 5.78 (0.71; 10.85) 0.026 0.018
CD4 + CD27 + CD28+ –0.55 (–5.92; 4.81) 0.836 8.72 (2.22; 15.22) 0.009 0.328
CD4+/central memory 2.65 (–0.57; 5.88) 0.105 6.44 (3.4; 9.48) <0.001 0.114
CD4 + CD27– 0.34 (0.11; 0.57) 0.005 –0.26 (–0.47; –0.04) 0.020 <0.001
CD4+/TEMRA 0.23 (0.03; 0.43) 0.028 –0.09 (–0.28; 0.1) 0.343 0.008
CD8+ 7.69 (2.62; 12.75) 0.004 4.04 (–0.72; 8.8) 0.095 0.116
CD8 + CD27+ –4.77 (–8.8; –0.74) 0.021 2.10 (–1.85; 6.06) 0.292 0.008
CD8 + CD28+ –5.53 (–11.3; 0.24) 0.060 3.99 (–2.84; 10.83) 0.246 0.011
CD8 + CD27 + CD28+ –4.31 (–8.15; –0.46) 0.029 3.91 (0.62; 7.2) 0.021 0.004
CD8 + CD27-CD28– 6.35 (1.78; 10.92) 0.007 –4.42 (–9.18; 0.35) 0.068 <0.001
CD8+/central memory –0.15 (–0.35; 0.05) 0.130 0.27 (0.07; 0.48) 0.009 0.01
CD8+/naive –0.16 (–0.40; 0.09) 0.204 0.29 (0.06; 0.52) 0.014 0.151
CD4/CD8 ratio –0.19 (–0.32; –0.07) 0.003 0.02 (–011; 0.15) 0.757 0.022
CD4 + CD25hi FOXP3+ –0.02 (–0.19; 0.15) 0.857 0.17 (0.02; 0.33) 0.028 0.185
CD4 + Helios+ –0.07 (–1.14; 1.01) 0.903 0.99 (0.18; 1.8) 0.017 0.511
Lin-CD14+ 0.20 (–0.07; 0.47) 0.151 0.58 (0.33; 0.83) <0.001 0.021
CD14 + HLA-DR– 0.13 (0.01; 0.26) 0.039 0.21 (0.08; 0.34) 0.002 0.591
CD14 + CD124+ 0.06 (0.01; 0.11) 0.014 0.07 (0.02; 0.12) 0.009 0.092
CD15+ 0.44 (0.04; 0.83) 0.031 –0.57 (–1.15; 0.01) 0.054 0.018
  1. Mean differences are shown in measurements made at inclusion and at 3 months (n = 28) and at inclusion and at 1 year (n = 28) in the chemotherapy group (CTG), and these were compared to patients who did not receive chemotherapy (Time by group interaction) (n = 28). Only cell populations with statistically significant relationships are shown. Naïve CD45RA + CCR7 + CD27 + CD28+, Central memory CD45RA-CCR7 + CD27 + CD28+, TEMRA CD45RA + CCR7-CD27-CD28–. P values in bold are statistically significant