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Table 1 Top five molecular subtype levels ranked according to correlation to each COCA cluster

From: Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

COCA cluster 1 COCA cluster 2 COCA cluster 3 COCA cluster 4 COCA cluster 5 COCA cluster 6
miRNA2 (0.80) PAM50 - LumB (0.82) IntClust10 (0.83) PAM50 - LumA (0.63) miRNA4 (0.55) PAM50 - HER2 (0.73)
PAM50 - LumA (0.23) PARADIGM1 (0.55) PAM50 - Basal (0.76) miRNA1 (0.45) PAM50 - Normal (0.43) IntClust5 (0.69)
PARADIGM6 (0.15) miRNA1 (0.32) PARADIGM2 (0.71) RPPA - Luminal (0.30) RPPA - ReacI (0.25) RPPA - HER2 (0.68)
IntClust4 (0.12) IntClust1 (0.28) RPPA - Basal (0.67) IntClust3 (0.29) Metabolic2 (0.15) CAAI3 (0.28)
PARADIGM5 (0.12) IntClust9 (0.27) miRNA3 (0.40) PARADIGM4 (0.27) miRNA3 (0.13) PARADIGM2 (0.28)
  1. Values in parentheses are the Pearson correlation values. Correlation ≥0.3 (p < 0.001 for all) is indicated in bold font. COCA cluster-of-clusters analysis, LumA luminal A, PARADIGM pathway recognition algorithm using data integration on genomic model, IntClust integrated clusters, RPPA reverse-phase protein array, CAAI complex arm aberration index