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Table 1 Top five molecular subtype levels ranked according to correlation to each COCA cluster

From: Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

COCA cluster 1 COCA cluster 2 COCA cluster 3 COCA cluster 4 COCA cluster 5 COCA cluster 6
miRNA2 (0.80) PAM50 - LumB (0.82) IntClust10 (0.83) PAM50 - LumA (0.63) miRNA4 (0.55) PAM50 - HER2 (0.73)
PAM50 - LumA (0.23) PARADIGM1 (0.55) PAM50 - Basal (0.76) miRNA1 (0.45) PAM50 - Normal (0.43) IntClust5 (0.69)
PARADIGM6 (0.15) miRNA1 (0.32) PARADIGM2 (0.71) RPPA - Luminal (0.30) RPPA - ReacI (0.25) RPPA - HER2 (0.68)
IntClust4 (0.12) IntClust1 (0.28) RPPA - Basal (0.67) IntClust3 (0.29) Metabolic2 (0.15) CAAI3 (0.28)
PARADIGM5 (0.12) IntClust9 (0.27) miRNA3 (0.40) PARADIGM4 (0.27) miRNA3 (0.13) PARADIGM2 (0.28)
  1. Values in parentheses are the Pearson correlation values. Correlation ā‰„0.3 (pā€‰<ā€‰0.001 for all) is indicated in bold font. COCA cluster-of-clusters analysis, LumA luminal A, PARADIGM pathway recognition algorithm using data integration on genomic model, IntClust integrated clusters, RPPA reverse-phase protein array, CAAI complex arm aberration index
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Breast Cancer Research

ISSN: 1465-542X

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