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Table 1 Top five molecular subtype levels ranked according to correlation to each COCA cluster

From: Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

COCA cluster 1

COCA cluster 2

COCA cluster 3

COCA cluster 4

COCA cluster 5

COCA cluster 6

miRNA2 (0.80)

PAM50 - LumB (0.82)

IntClust10 (0.83)

PAM50 - LumA (0.63)

miRNA4 (0.55)

PAM50 - HER2 (0.73)

PAM50 - LumA (0.23)

PARADIGM1 (0.55)

PAM50 - Basal (0.76)

miRNA1 (0.45)

PAM50 - Normal (0.43)

IntClust5 (0.69)

PARADIGM6 (0.15)

miRNA1 (0.32)

PARADIGM2 (0.71)

RPPA - Luminal (0.30)

RPPA - ReacI (0.25)

RPPA - HER2 (0.68)

IntClust4 (0.12)

IntClust1 (0.28)

RPPA - Basal (0.67)

IntClust3 (0.29)

Metabolic2 (0.15)

CAAI3 (0.28)

PARADIGM5 (0.12)

IntClust9 (0.27)

miRNA3 (0.40)

PARADIGM4 (0.27)

miRNA3 (0.13)

PARADIGM2 (0.28)

  1. Values in parentheses are the Pearson correlation values. Correlation ≥0.3 (p < 0.001 for all) is indicated in bold font. COCA cluster-of-clusters analysis, LumA luminal A, PARADIGM pathway recognition algorithm using data integration on genomic model, IntClust integrated clusters, RPPA reverse-phase protein array, CAAI complex arm aberration index