Fig. 2
Percentages of each pathway estrogen metabolites (2-catechols, methylated 2-catechols, 4-catechols, methylated 4-catechols, 16-pathway metabolites) out of summed child estrogen metabolites by current body mass index (BMI) among never/former menopausal hormone therapy users. Adjusted for age at blood draw (<55, 55-59, 60-64, 65-69, 70-74, 75-79 years), blood draw year (1993-1996, 1997-1998), race (white, non-white), smoking status (never, former, current), time since menopause (<10, 10-19, ≥20 years, missing), moderate- to vigorous-intensity physical activity (0, 0.1-9.9, ≥10 MET-hr/wk), summed concentration of child estrogen metabolites (continuous, pmol/L). Note: Summed child estrogen metabolites include the following estrogen metabolites: 2-catechols (2-hydroxyestrone, 2-hydroxyestradiol), methylated 2-catechols (conjugated and unconjugated 2-methoxyestrone, conjugated and unconjugated 2-methoxyestradiol, 2-hyroxyestrone-3-methyl ether), 4-catechols (4-hydroxyestrone), methylated 4-catechols (4-methoxyestrone, 4-methoxyestradiol), 16-pathway metabolites (16α-hydroxyestrone, conjugated and unconjugated estriol, 16-ketoestradiol, 16-epiestriol, 17-epiestriol). aFor 2-catechols, overall F-test p=0.89. bFor methylated 2-catechols, overall F-test p=0.001. P-values for comparing women with current BMI 25-29.9 vs. <25 kg/m2 was 0.002, comparing women with current BMI ≥30 vs. 25-29.9 kg/m2 was 0.57, and comparing women with current BMI ≥30 vs. <25 kg/m2 was 0.001. cFor 4-catechols, overall F-test p=0.59. dFor methylated 4-catechols, overall F-test p=0.0002. P-values for comparing women with current BMI 25-29.9 vs. <25 kg/m2 was <0.0001, comparing women with current BMI ≥30 vs. 25-29.9 kg/m2 was 0.82, and comparing women with current BMI ≥30 vs. <25 kg/m2 was 0.003. eFor 16-pathway metabolites, overall F-test p<0.0001. P-values for comparing women with current BMI 25-29.9 vs. <25 kg/m2 was 0.0003, comparing women with current BMI ≥30 vs. 25-29.9 kg/m2 was 0.78, and comparing women with current BMI ≥30 vs. <25 kg/m2 was 0.0002.BMI body mass index