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Fig. 1 | Breast Cancer Research

Fig. 1

From: Anthropometric measures and serum estrogen metabolism in postmenopausal women: the Women’s Health Initiative Observational Study

Fig. 1

Percentages of parent estrogens (estradiol and estrone) and child estrogen metabolites (2-, 4-, and 16-hydroxylation pathway metabolites) out of summed estrogens/estrogen metabolites by current body mass index (BMI) among never or former menopausal hormone therapy usersa. Adjusted for age at blood draw (<55, 55-59, 60-64, 65-69, 70-74, 75-79 years), blood draw year (1993-1996, 1997-1998), race (white, non-white), smoking status (never, former, current), time since menopause (<10, 10-19, ≥20 years, missing), moderate- to vigorous-intensity physical activity (0, 0.1-9.9, ≥10 MET-hr/wk), summed concentration of estrogens/estrogen metabolites (continuous, pmol/L).Note: Summed estrogens/estrogen metabolites include the summed concentration of parent estrogens (estrone, estradiol) and child metabolites (2-hydroxyestrone, 2-hydroxyestradiol, 2-methoxyestrone, 2-methoxyestradiol, 2-hyroxyestrone-3-methyl ether, 4-hydroxyestrone, 4-methoxyestrone, 4-methoxyestradiol, 16α-hydroxyestrone, estriol, 16-ketoestradiol, 16-epiestriol, 17-epiestriol).aOverall F-test p=0.02.b P-value for comparing percent parent estrogens between women with current BMI 25-29.9 vs. <25 kg/m2 was 0.11.c P-value for comparing percent parent estrogens between women with current BMI ≥30 vs. 25-29.9 kg/m2 was 0.10. P-value for comparing percent parent estrogens between women with current BMI ≥30 vs. <25 kg/m2 was 0.006.BMI body mass index

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