Fig. 4

Warburg effect in mammary gland tumor tissue of chronically insulin analogue treated mice. a Hierarchical clustering (Pearson correlation) of genes involved in glycolysis or oxidative phosphorylation per MG tumor. The pie diagrams show the distribution of the different clusters per treatment group. b Table with the metabolic pathways that were significantly down- or upregulated in the X10/IGF1 treatment groups compared to the vehicle, insulin, and glargine treatment groups. c Table with the metabolic pathways that were significantly down- or upregulated after X10/IGF1 exposure compared to vehicle, insulin, and glargine treatment in the MCF7 IGF1R model