Luminal A-like | Luminal B-like HER2-negative | Luminal B-like HER2-positive | HER2-positive | Triple-negative | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ER+ PR+ HER2- | ER+ PR- HER2- | ER+ PR+/PR- HER2+ | ER- PR- HER2+ | ER- PR- HER2- | ||||||||||||||||
Controls (n) | Cases (n) | OR* | 95% CI | Controls (n) | Cases (n) | OR | 95% CI | Controls (n) | Cases (n) | OR | 95% CI | Controls (n) | Cases (n) | OR | 95% CI | Controls (n) | Cases (n) | OR | 95% CI | |
Age at start of oral contraceptives (years) | ||||||||||||||||||||
14–18 | 1476 | 285 | 1 | Reference | 334 | 65 | 1 | Reference | 187 | 45 | 1 | Reference | 128 | 17 | 1 | Reference | 180 | 55 | 1 | Reference |
19–20 | 1462 | 387 | 1.33 | (1.11, 1.59) | 367 | 87 | 1.20 | (0.82, 1.75) | 230 | 49 | 0.90 | (0.55, 1.45) | 133 | 27 | 1.52 | (0.75, 3.10) | 206 | 46 | 0.67 | (0.42, 1.07) |
21–24 | 1959 | 405 | 1.05 | (0.87, 1.25) | 458 | 92 | 1.04 | (0.71, 1.53) | 295 | 45 | 0.62 | (0.37, 1.02) | 130 | 24 | 1.45 | (0.69, 3.04) | 253 | 41 | 0.44 | (0.27, 0.74) |
25–50 | 1993 | 397 | 0.99 | (0.83, 1.20) | 536 | 102 | 0.97 | (0.66, 1.43) | 296 | 58 | 0.80 | (0.49, 1.32) | 114 | 27 | 2.23 | (1.06, 4.71) | 258 | 58 | 0.63 | (0.39, 1.03) |
Never used | 6715 | 1344 | 1.01 | (0.86, 1.19) | 1758 | 363 | 0.99 | (0.71, 1.38) | 876 | 180 | 0.82 | (0.53, 1.27) | 501 | 115 | 2.05 | (1.08, 3.89) | 860 | 165 | 0.54 | (0.36, 0.81) |
p-trenda | 0.09 | 0.43 | 0.71 | 0.02 | 0.03 | |||||||||||||||
p-heterogeneity# | 0.60 | 0.52 | 0.07 | 0.02 | ||||||||||||||||
Duration of oral contraceptives (years) | ||||||||||||||||||||
Never used | 6715 | 1344 | 1 | Reference | 1758 | 363 | 1 | Reference | 876 | 180 | 1 | Reference | 501 | 115 | 1 | Reference | 860 | 165 | 1 | Reference |
<2 | 1839 | 364 | 0.97 | (0.85, 1.11) | 482 | 80 | 0.82 | (0.62, 1.08) | 275 | 34 | 0.64 | (0.42, 0.97) | 151 | 18 | 0.47 | (0.27, 0.81) | 263 | 43 | 0.85 | (0.58, 1.26) |
2–5 | 1753 | 361 | 1.03 | (0.90, 1.18) | 435 | 88 | 1.01 | (0.77, 1.33) | 233 | 48 | 0.94 | (0.64, 1.37) | 113 | 17 | 0.61 | (0.34, 1.09) | 228 | 56 | 1.32 | (0.92, 1.89) |
6–10 | 1568 | 332 | 1.06 | (0.92, 1.23) | 388 | 80 | 1.03 | (0.77, 1.37) | 240 | 56 | 1.23 | (0.85, 1.76) | 121 | 35 | 1.07 | (0.66, 1.73) | 203 | 47 | 1.20 | (0.82, 1.76) |
>10 | 1266 | 298 | 1.11 | (0.96, 1.29) | 271 | 62 | 1.12 | (0.81, 1.54) | 204 | 45 | 0.95 | (0.64, 1.42) | 82 | 19 | 1.02 | (0.56, 1.86) | 149 | 38 | 1.25 | (0.82, 1.90) |
p-trend* | 0.13 | 0.51 | 0.57 | 0.91 | 0.11 | |||||||||||||||
p-heterogeneity# | 0.61 | 0.10 | 0.003 | 0.56 | ||||||||||||||||
Age at start of intrauterine device (years) | ||||||||||||||||||||
14–28 | 612 | 125 | 1 | Reference | 152 | 28 | 1 | Reference | 82 | 14 | 1 | Reference | 55 | 12 | 1 | Reference | 88 | 19 | 1 | Reference |
29–35 | 681 | 143 | 0.97 | (0.73, 1.28) | 152 | 39 | 1.31 | (0.75, 2.30) | 93 | 10 | 0.76 | (0.30, 1.90) | 46 | 7 | 0.74 | (0.24, 2.25) | 78 | 25 | 1.42 | (0.70, 2.88) |
36–42 | 532 | 147 | 1.33 | (1.00, 1.77) | 114 | 21 | 0.83 | (0.43, 1.58) | 89 | 19 | 1.34 | (0.60, 3.01) | 43 | 7 | 0.75 | (0.26, 2.16) | 78 | 12 | 0.70 | (0.31, 1.58) |
43 − 50 | 456 | 121 | 1.16 | (0.86, 1.56) | 136 | 25 | 0.86 | (0.46, 1.59) | 70 | 11 | 1.06 | (0.42, 2.70) | 39 | 7 | 0.94 | (0.32, 2.78) | 70 | 14 | 0.94 | (0.42, 2.12) |
Never used | 10000 | 2025 | 0.93 | (0.75, 1.15) | 2600 | 529 | 0.94 | (0.61, 1.45) | 1368 | 284 | 1.36 | (0.72, 2.56) | 729 | 153 | 1.10 | (0.56, 2.16) | 1279 | 267 | 0.94 | (0.55, 1.61) |
p-trenda | 0.07 | 0.34 | 0.10 | 0.40 | 0.45 | |||||||||||||||
p-heterogeneity# | 0.22 | 0.12 | 0.20 | 0.38 | ||||||||||||||||
Duration of intrauterine device (years) | ||||||||||||||||||||
Never used | 10000 | 2025 | 1 | Reference | 2600 | 529 | 1 | Reference | 1368 | 284 | 1 | Reference | 729 | 153 | 1 | Reference | 1279 | 267 | 1 | Reference |
<2 | 341 | 64 | 0.91 | (0.69, 1.21) | 83 | 16 | 0.86 | (0.49, 1.52) | 56 | 13 | 1.23 | (0.62, 2.43) | 33 | 5 | 0.84 | (0.31, 2.32) | 37 | 7 | 0.90 | (0.38, 2.13) |
2–5 | 432 | 104 | 1.17 | (0.93, 1.48) | 112 | 21 | 0.95 | (0.58, 1.56) | 62 | 11 | 0.96 | (0.47, 1.94) | 36 | 7 | 0.81 | (0.34, 1.91) | 57 | 21 | 1.79 | (1.01, 3.16) |
6–10 | 615 | 140 | 1.16 | (0.95, 1.42) | 153 | 40 | 1.37 | (0.94, 2.01) | 89 | 15 | 0.86 | (0.46, 1.59) | 53 | 8 | 0.62 | (0.27, 1.43) | 99 | 20 | 1.23 | (0.72, 2.11) |
>10 | 820 | 212 | 1.35 | (1.14, 1.61) | 176 | 31 | 0.96 | (0.63, 1.46) | 111 | 12 | 0.51 | (0.27, 0.96) | 63 | 12 | 0.73 | (0.37, 1.47) | 120 | 20 | 0.75 | (0.44, 1.28) |
p-trend | <0.0001 | 0.52 | 0.06 | 0.18 | 0.98 | |||||||||||||||
p-heterogeneity# | 0.08 | 0.01 | 0.65 | 0.22 | ||||||||||||||||
Hormone therapy use | ||||||||||||||||||||
Never | 7411 | 1356 | 1 | Reference | 1762 | 356 | 1 | Reference | 1010 | 195 | 1 | Reference | 573 | 113 | 1 | Reference | 991 | 196 | 1 | Reference |
Past | 4809 | 1086 | 1.27 | (1.15, 1.40) | 1361 | 276 | 0.98 | (0.81, 1.18) | 688 | 142 | 1.07 | (0.81, 1.42) | 319 | 65 | 0.88 | (0.60, 1.30) | 575 | 126 | 1.04 | (0.79, 1.38) |
Estrogen current | 655 | 131 | 1.06 | (0.86, 1.31) | 162 | 31 | 0.81 | (0.53, 1.23) | 85 | 19 | 1.14 | (0.65, 1.99) | 51 | 12 | 1.12 | (0.54, 2.35) | 93 | 16 | 0.79 | (0.43, 1.46) |
Estrogen and progesterone current | 345 | 184 | 2.92 | (2.36, 3.62) | 89 | 33 | 1.74 | (1.10, 2.74) | 48 | 18 | 1.67 | (0.89, 3.14) | 32 | 6 | 0.88 | (0.33, 2.30) | 49 | 10 | 0.92 | (0.43, 1.98) |
p-trend | <0.0001 | 0.34 | 0.15 | 0.77 | 0.72 | |||||||||||||||
p-heterogeneity# | 0.05 | 0.34 | 0.03 | 0.01 | ||||||||||||||||
Duration of hormone therapy (years) | ||||||||||||||||||||
Never | 7411 | 1356 | 1 | Reference | 1762 | 356 | 1 | Reference | 1010 | 195 | 1 | Reference | 573 | 113 | 1 | Reference | 991 | 196 | 1 | Reference |
< =3 | 1625 | 306 | 1.09 | (0.94, 1.26) | 473 | 96 | 0.99 | (0.76, 1.30) | 237 | 43 | 0.90 | (0.61, 1.34) | 134 | 20 | 0.66 | (0.38, 1.16) | 234 | 41 | 0.77 | (0.52, 1.15) |
4–8 | 1130 | 240 | 1.21 | (1.03, 1.43) | 289 | 64 | 1.06 | (0.77, 1.46) | 155 | 35 | 1.19 | (0.76, 1.87) | 76 | 19 | 1.18 | (0.65, 2.13) | 119 | 25 | 0.99 | (0.59, 1.67) |
>8 | 1756 | 555 | 1.84 | (1.61, 2.11) | 485 | 112 | 1.24 | (0.95, 1.61) | 253 | 63 | 1.34 | (0.91, 1.98) | 108 | 23 | 0.93 | (0.52, 1.65) | 222 | 47 | 1.04 | (0.69, 1.56) |
p-trend | <0.0001 | 0.15 | 0.14 | 0.94 | 1.00 | |||||||||||||||
p-heterogeneity# | 0.001 | 0.48 | 0.11 | 0.02 | ||||||||||||||||
Duration of estrogen and progesterone therapy (years) | ||||||||||||||||||||
Never | 7411 | 1356 | 1 | Reference | 1762 | 356 | 1 | Reference | 1010 | 195 | 1 | Reference | 573 | 113 | 1 | Reference | 991 | 196 | 1 | Reference |
< =5 | 1908 | 412 | 1.25 | (1.09, 1.43) | 545 | 114 | 1.02 | (0.79, 1.32) | 276 | 45 | 0.79 | (0.53, 1.17) | 153 | 30 | 0.92 | (0.56, 1.53) | 230 | 54 | 1.19 | (0.81, 1.74) |
> 5 | 1796 | 561 | 1.80 | (1.58, 2.06) | 496 | 116 | 1.18 | (0.90, 1.54) | 256 | 71 | 1.47 | (1.00, 2.16) | 105 | 29 | 1.04 | (0.62, 1.74) | 211 | 52 | 1.34 | (0.89, 2.02) |
p-trend | <0.0001 | 0.31 | 0.27 | 0.98 | 0.13 | |||||||||||||||
p-heterogeneity# | 0.004 | 0.19 | 0.19 | 0.02 |