Fig. 7
From: The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis
GLUT1 inhibition or glucose restriction reduces cell proliferation in 3D acinar structures. a Quantification of percent BrdU-positive cells in 3D acinar structures grown in 17.5 mM or 2.5 mM glucose, with and without WZB117. Groups with the same letter (a, b, c) are significantly different from each other, p < 0.05 by Mann-Whitney tests. Representative images, taken 8 days after seeding, of acinar structures grown in 17.5 mM glucose without BB homodimerizer to activate ERBB2 (b), with BB homodimerizer, added at day 6 of culture, in 17.5 mM glucose (c), with BB homodimerizer and 15 μM WZB117 added at day 6 of culture, in 17.5 mM media (d), or with BB homodimerizer added and switched to 2.5 mM glucose at day 6 of culture (e). Scale bars in images are 100 μm