Fig. 5
From: The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis
Nuclear Cre recombinase is not expressed in normal mammary epithelium of mice lacking GLUT1. Representative images of Cre staining from NIC-GLUT1+/+ (a), NIC-GLUT1F/+ (b), NIC-GLUT1F/F (c), and wild-type FVB (d) mice. Inset in d is a wild-type FVB gland no-primary control. Scale bars for images are 100 μm. e Quantification of percent cells positive for nuclear Cre recombinase (Cre) in non-tumor-bearing mammary glands. Groups with the same letter (a, b) are significantly different from each other, p < 0.05 by Mann-Whitney tests. N = 4 mice per group. FACS analysis of mammary cell populations Lin-CD24+CD29hi (f) and Lin-CD24+CD29loCD61+ (g) from wild-type (WT) FVB (N = 7), NIC-GLUT1+/+ (N = 4), NIC-GLUT1F/+ (N = 4), and NIC-GLUT1F/F (N = 4) mice