Fig. 4
From: The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis
GLUT1 expression decreases with increasing tumor size. a GLUT1 protein levels are inversely correlated with tumor size. Spearman correlation r = –0.67; p < 0.0001; N = 81 tumors. Representative images of GLUT1 staining in small (b) and large (c) mammary tumors from NIC-GLUT1+/+ mice. Scale bars in images are 200 μm. Immunohistochemistry of Cre (d) and GLUT1 (e) expression in a small, non-palpable lesion in serial sections from a NIC-GLUT1+/+ mouse. f Analysis of SLC2A1 expression in normal breast tissue (Normal), ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC) reported in GSE59246. Groups with the same letter (a, b) are significantly different from each other, p < 0.05 by unpaired t tests