Fig. 3
From: The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis
Reduced proliferation in mammary epithelium of mice lacking GLUT1. a Quantification of percent Ki67-positive epithelial cells in tumor tissue and in non-tumor-bearing mammary glands. Ki67 levels were significantly lower in NIC-GLUT1F/+ and NIC-GLUT1F/F compared to NIC-GLUT1+/+ mammary epithelium. Groups with the same letter (a, b) are significantly different from each other, p < 0.05 by Mann-Whitney test. Ki67 levels in tumors and in mammary epithelium from wild-type (WT) FVB are shown for reference. Representative images of Ki67-stained tissue from a NIC-Glut1+/+ tumor (b) and non-tumor-bearing gland (c), and non-tumor-bearing glands from NIC-Glut1F/+ (d) and NIC-Glut1F/F (e) mice. Scale bars for images are 200 μm