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Fig. 1 | Breast Cancer Research

Fig. 1

From: The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis

Fig. 1

Loss of GLUT1 prevents HER2/ERBB2/Neu-induced mammary tumor development. a Kaplan-Meier curve of tumor-free survival in MMTV-NIC mice with wild-type GLUT1 (Glut1 +/+), one floxed GLUT1 allele (Glut1 F/+) or two floxed GLUT1 alleles (Glut1 F/F). N = 17, 8, and 13 mice per group, respectively, for GLUT1+/+, GLUT1F/+, and GLUT1F/F. Vertical marks on the curves for NIC-GLUTF/F and NIC-GLUTF/+ indicate times at which animals were sacrificed for analysis (censored subjects). Whole mounted mammary glands (b–e) from NIC-GLUT1F/+ (b, d) and NIC-GLUT1F/F (c, e) nulliparous adult female mice. Images b and c were captured at 4× magnification, and images d and e were captured at 10× magnification. H&E-stained sections of mammary glands from NIC-GLUT1F/+ (f), NIC-GLUT1F/F (g), wild-type FVB (h), and NIC-GLUT1+/+ (i) nulliparous adult female mice. Scale bars for H&E images are 300 μm

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